4-[(3-fluorophenyl)amino]-6-methoxy-7-(3,6,9,12-tetraoxapentadecan-14-ynyloxy)quinazoline

Base Information

Chemical Name:4-[(3-fluorophenyl)amino]-6-methoxy-7-(3,6,9,12-tetraoxapentadecan-14-ynyloxy)quinazoline
CAS No.:1236153-18-6
Molecular Formula:C₂₆H₃₀FN₃O₆
Molecular Weight:499.539
Hs Code.:

Synonyms:4-[(3-fluorophenyl)amino]-6-methoxy-7-(3,6,9,12-tetraoxapentadecan-14-ynyloxy)quinazoline

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Chemical Property of 4-[(3-fluorophenyl)amino]-6-methoxy-7-(3,6,9,12-tetraoxapentadecan-14-ynyloxy)quinazoline

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Technology Process of 4-[(3-fluorophenyl)amino]-6-methoxy-7-(3,6,9,12-tetraoxapentadecan-14-ynyloxy)quinazoline

There total 9 articles about 4-[(3-fluorophenyl)amino]-6-methoxy-7-(3,6,9,12-tetraoxapentadecan-14-ynyloxy)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 875770-32-4
toluene-4-sulfonic acid 2-{2-[2-(2-ethynyloxyethoxy)-ethoxy]-ethoxy}-ethyl ester

: 1236153-17-5
C₁₅H₁₂FN₃O₂

: 1236153-18-6
4-[(3-fluorophenyl)amino]-6-methoxy-7-(3,6,9,12-tetraoxapentadecan-14-ynyloxy)quinazoline

Guidance literature:: With potassium carbonate; In acetonitrile; at 60 ℃; for 24h;

Reference yield: 38.0%

: 1236153-17-5
C₁₅H₁₂FN₃O₂

: 87450-10-0
3,6,9,12-tetraoxapentadec-14-yn-1-ol

: 1236153-18-6
4-[(3-fluorophenyl)amino]-6-methoxy-7-(3,6,9,12-tetraoxapentadecan-14-ynyloxy)quinazoline

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 20 ℃;

Reference yield:

: 1236153-16-4
4-(3-fluoroanilino)-6-methoxy-7-benzyloxyquinazoline

: 1236153-18-6
4-[(3-fluorophenyl)amino]-6-methoxy-7-(3,6,9,12-tetraoxapentadecan-14-ynyloxy)quinazoline

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane

2: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 16 h / 20 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; trifluoroacetic acid; In dichloromethane; 2: Mitsunobu reaction;
DOI:10.1016/j.tetlet.2010.11.107