1-(1-Pyrrolidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-trifluoromethyl-phenyl)-ethanone

Base Information

Chemical Name:1-(1-Pyrrolidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-trifluoromethyl-phenyl)-ethanone
CAS No.:135709-89-6
Molecular Formula:C₂₃H₂₅F₃N₂O
Molecular Weight:402.46
Hs Code.:

Synonyms:1-(1-Pyrrolidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-trifluoromethyl-phenyl)-ethanone

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Chemical Property of 1-(1-Pyrrolidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-trifluoromethyl-phenyl)-ethanone

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Technology Process of 1-(1-Pyrrolidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-trifluoromethyl-phenyl)-ethanone

There total 6 articles about 1-(1-Pyrrolidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-trifluoromethyl-phenyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74426-51-0
4-(trifluoromethyl)phenylacetyl chloride

: 112217-71-7
1-(pyrrolidin-1-yl)methyl-1,2,3,4-tetrahydroisoquinoline

: 135709-89-6
1-(1-Pyrrolidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-trifluoromethyl-phenyl)-ethanone

Guidance literature:: With potassium carbonate; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jm00112a042

Reference yield:

: 13156-95-1
2-chloro-N-phenethylacetamide

: 135709-89-6
1-(1-Pyrrolidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-trifluoromethyl-phenyl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: P₂O₅ / xylene / 3 h / 140 °C

2: methanol / Ambient temperature

3: sodium borohydride / 2 h / 0 °C

4: K₂CO₃ / CH₂Cl₂ / 3 h / 0 °C

With sodium tetrahydroborate; phosphorus pentoxide; potassium carbonate; In methanol; dichloromethane; xylene;
DOI:10.1021/jm00112a042

Reference yield:

: 32857-62-8
4-Trifluoromethylphenylacetic acid

: 135709-89-6
1-(1-Pyrrolidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-trifluoromethyl-phenyl)-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride / CHCl₃ / Ambient temperature

2: K₂CO₃ / CH₂Cl₂ / 3 h / 0 °C

With oxalyl dichloride; potassium carbonate; In dichloromethane; chloroform;
DOI:10.1021/jm00112a042