74426-51-0

Basic information

• Product Name: 4-(TRIFLUOROMETHYL)PHENYLACETYL CHLORID
• Synonyms: 4-(TRIFLUOROMETHYL)PHENYLACETYL CHLORID;4-(2-Chloro-2-oxoethyl)benzotrifluoride, 4-[(Chlorocarbonyl)methyl]benzotrifluoride;4-(Trifluoromethyl)phenylacetylchloride95%
• CAS NO: 74426-51-0
• Molecular Formula: C₉H₆ClF₃O
• Molecular Weight: 222.5915496
• Mol File: 74426-51-0.mol
• Article Data: 43

Chemical Properties

• Boiling Point: 230.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.355±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-(TRIFLUOROMETHYL)PHENYLACETYL CHLORID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHYL)PHENYLACETYL CHLORID(74426-51-0)
• EPA Substance Registry System: 4-(TRIFLUOROMETHYL)PHENYLACETYL CHLORID(74426-51-0)

Safety Data

• Hazardous Substances Data: 74426-51-0(Hazardous Substances Data)

Upstream product

• 32857-62-8 4-Trifluoromethylphenylacetic acid 

Downstream Products

• 1027995-92-1 (4-Trifluoromethyl-phenyl)-acetic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester 
• 433682-93-0 methyl 7-methoxy-2-(4'-trifluoromethylbenzyl)-4H-1-benzopyran-4-one-3-carboxylate 
• 433682-95-2 7-methoxy-2-(4'-trifluoromethylbenzyl)-4H-1-benzopyran-4-one 
• 433682-94-1 7-methoxy-2-(4'-trifluoromethylbenzyl)-4H-1-benzopyran-4-one-3-carboxylic acid 
• 134469-33-3 1-(pyrrolidin-1-yl)methyl-2-(4-trifluoromethylphenyl)acetyl-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline 
• 848678-58-0 C₉H₆F₃N₃O 
• 130926-30-6 1-((S)-1-Pyrrolidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-trifluoromethyl-phenyl)-ethanone 
• 135909-61-4 1-(1-Pyrrolidin-1-ylmethyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-(4-trifluoromethyl-phenyl)-ethanone 
• 32857-62-8 4-Trifluoromethylphenylacetic acid 

Relevant articles and documents

Preparation method of N-phenylacetyl-2-hydroxymethylpyrrolidine-2-formamide and medicinal application of N-phenylacetyl-2-hydroxymethylpyrrolidine-2-formamide

The invention discloses N-phenylacetyl-2-hydroxymethylpyrrolidine-2-formamide as shown in a general formula (I), a preparation method of the compound, a new application of the compound and a pharmaceutical composition containing the compound in the aspect of inhibiting neuroglial cell inflammation. Wherein R1/R2 is equal to H, F, CF3 or OCF3.

Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation

Axl has emerged as an attractive target for cancer therapy due to its strong correlation with tumor growth, metastasis, poor survival, and drug resistance. Herein, we report the design, synthesis and structure-activity relationship (SAR) investigation of a series of pyrrolo[2,3-d]pyrimidine derivatives as new Axl inhibitors. Among them, the most promising compound 13b showed high enzymatic and cellular Axl potencies. Furthermore, 13b possessed preferable pharmacokinetic properties and displayed promising therapeutic effect in BaF3/TEL-Axl xenograft tumor model. Compound 13b may serve as a lead compound for new antitumor drug discovery.

Phosphonic acid analogs of fluorophenylalanines as inhibitors of human and porcine aminopeptidases N: Validation of the importance of the substitution of the aromatic ring

A library of phosphonic acid analogs of phenylalanine substituted with fluorine, chlorine and trifluoromethyl moieties on the aromatic ring was synthesized and evaluated for inhibitory activity against human (hAPN) and porcine (pAPN) aminopeptidases. Fluorogenic screening indicated that these analogs are micromolar or submicromolar inhibitors, both enzymes being more active against hAPN. In order to better understand the mode of the action of the most active compounds, molecular modeling was used. It confirmed that aminophosphonic portion of the enzyme is bound nearly identically in the case of all the studied compounds, whereas the difference in activity results from the placement of aromatic side chain of an inhibitor. Interestingly, both enantiomers of the individual compounds are usually bound quite similarly.