tert-butyl 4-(4-bromothiazol-2-yl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(4-bromothiazol-2-yl)piperazine-1-carboxylate
• CAS No.: 1197294-66-8
• Molecular Formula: C₁₂H₁₈BrN₃O₂S
• Molecular Weight: 348.264
• Mol file: 1197294-66-8.mol

Synonyms:tert-butyl 4-(4-bromothiazol-2-yl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-(4-bromothiazol-2-yl)piperazine-1-carboxylate

Chemical Property:

• Boiling Point: 426.2±55.0 °C(Predicted)
• PKA: 3.53±0.10(Predicted)
• Density: 1.458±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl4-(4-Bromothiazol-2-yl)piperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(4-bromothiazol-2-yl)piperazine-1-carboxylate

There total 1 articles about tert-butyl 4-(4-bromothiazol-2-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2,4-dibromo-1,3-thiazole (4175-77-3) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(4-bromothiazol-2-yl)piperazine-1-carboxylate (1197294-66-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 45h;

Reference yield: 73.0%

tert-butyl 4-(4-bromothiazol-2-yl)piperazine-1-carboxylate (1197294-66-8) + 4-methoxyphenylboronic acid (5720-07-0) → tert-butyl 4-(4-(4-methoxyphenyl)thiazol-2-yl)piperazine-1-carboxylate

Guidance literature:

4-methoxyphenylboronic acid; With potassium carbonate; In water; for 0.5h;

tert-butyl 4-(4-bromothiazol-2-yl)piperazine-1-carboxylate; With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In water; at 55 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.joc.0c00929

Reference yield: 72.0%

2-fluoro-4-methylphenylboronic acid (170981-26-7) + tert-butyl 4-(4-bromothiazol-2-yl)piperazine-1-carboxylate (1197294-66-8) → tert-butyl 4-(4-(2-fluoro-4-methylphenyl)thiazol-2-yl)piperazine-1-carboxylate

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; for 4h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2015.12.026

upstream raw materials:

2,4-dibromo-1,3-thiazole

1-t-Butoxycarbonylpiperazine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1197294-66-8 tert-butyl 4-(4-bromothiazol-2-yl)piperazine-1-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send