2-Amino-3,5-diphenylpyrazine

Base Information

• Chemical Name: 2-Amino-3,5-diphenylpyrazine
• CAS No.: 41270-70-6
• Molecular Formula: C₁₆H₁₃N₃
• Molecular Weight: 247.299
• DSSTox Substance ID: DTXSID30436550
• Nikkaji Number: J613.434C
• Mol file: 41270-70-6.mol

Synonyms:3,5-diphenylpyrazin-2-amine;2-Amino-3,5-diphenylpyrazine;41270-70-6;SCHEMBL6701248;DTXSID30436550;AKOS037651039;CS-15759;CS-0043261;FT-0767719;D72696

Chemical Property of 2-Amino-3,5-diphenylpyrazine

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 247.110947427
• Heavy Atom Count: 19
• Complexity: 269

Purity/Quality:

97% ^*data from raw suppliers

3,5-Diphenylpyrazin-2-amine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CN=C(C(=N2)C3=CC=CC=C3)N

Technology Process of 2-Amino-3,5-diphenylpyrazine

There total 10 articles about 2-Amino-3,5-diphenylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-amino-3,5-dibromopyrazine (24241-18-7) + phenylboronic acid (98-80-6) → 2-amino-3,5-diphenylpyrazine (41270-70-6)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; Heating;

DOI:10.3987/COM-03-9977

Reference yield: 86.0%

2-azido-3,5-diphenylpyrazine (76849-28-0) → 2-amino-3,5-diphenylpyrazine (41270-70-6)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; In methanol; at 60 ℃; for 4h;

DOI:10.1055/s-1994-25607

Reference yield: 84.0%

2-chloro-3,5-diphenylpyrazine (41270-63-7) → 2-amino-3,5-diphenylpyrazine (41270-70-6)

Guidance literature:

With benzamide; potassium carbonate; at 180 - 230 ℃; for 1h;

upstream raw materials:

2-azido-3,5-diphenylpyrazine

acetamide

2-chloro-3,5-diphenylpyrazine

tributylphenylstannane

Downstream raw materials:

2-acetamino-3,5-diphenylpyrazine