rac-tert-butyl N-[1-(3-bromophenyl)-1-(1H-pyrazol-3-yl)ethyl]carbamate

Base Information

Chemical Name:rac-tert-butyl N-[1-(3-bromophenyl)-1-(1H-pyrazol-3-yl)ethyl]carbamate
CAS No.:1369542-97-1
Molecular Formula:C₁₆H₂₀BrN₃O₂
Molecular Weight:366.258
Hs Code.:

Synonyms:rac-tert-butyl N-[1-(3-bromophenyl)-1-(1H-pyrazol-3-yl)ethyl]carbamate

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Chemical Property of rac-tert-butyl N-[1-(3-bromophenyl)-1-(1H-pyrazol-3-yl)ethyl]carbamate

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Technology Process of rac-tert-butyl N-[1-(3-bromophenyl)-1-(1H-pyrazol-3-yl)ethyl]carbamate

There total 8 articles about rac-tert-butyl N-[1-(3-bromophenyl)-1-(1H-pyrazol-3-yl)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1369542-96-0
rac-tert-butyl N-[1-(3-bromophenyl)-1-methyl-2-oxo-but-3-ynyl]carbamate

: 1369542-97-1
rac-tert-butyl N-[1-(3-bromophenyl)-1-(1H-pyrazol-3-yl)ethyl]carbamate

Guidance literature:: With hydrazine hydrate; In ethanol; at 20 ℃; for 1h;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1369542-97-1
rac-tert-butyl N-[1-(3-bromophenyl)-1-(1H-pyrazol-3-yl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonia; ammonium chloride / methanol / 96 h / 20 °C

2.1: hydrogenchloride / 96 h / Reflux

2.2: pH 8

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran / 15.17 h / 0 - 20 °C

4.2: pH 1 - 2 / Cooling with ice

5.1: Dess-Martin periodane / dichloromethane / 1.25 h / 0 - 20 °C

6.1: tetrahydrofuran / 0.75 h / 0 - 20 °C / Inert atmosphere

7.1: Dess-Martin periodane / dichloromethane / 1.25 h / 0 - 20 °C

8.1: hydrazine hydrate / ethanol / 1 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; ammonia; sodium hydrogencarbonate; ammonium chloride; Dess-Martin periodane; hydrazine hydrate; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 953741-63-4
rac-2-amino-2-(3-bromo-phenyl)-propionitrile

: 1369542-97-1
rac-tert-butyl N-[1-(3-bromophenyl)-1-(1H-pyrazol-3-yl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / 96 h / Reflux

1.2: pH 8

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran / 15.17 h / 0 - 20 °C

3.2: pH 1 - 2 / Cooling with ice

4.1: Dess-Martin periodane / dichloromethane / 1.25 h / 0 - 20 °C

5.1: tetrahydrofuran / 0.75 h / 0 - 20 °C / Inert atmosphere

6.1: Dess-Martin periodane / dichloromethane / 1.25 h / 0 - 20 °C

7.1: hydrazine hydrate / ethanol / 1 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydrogencarbonate; Dess-Martin periodane; hydrazine hydrate; In tetrahydrofuran; ethanol; dichloromethane;