rac-tert-butyl N-[1-(3-bromophenyl)-1-methyl-2-oxo-but-3-ynyl]carbamate

Base Information

Chemical Name:rac-tert-butyl N-[1-(3-bromophenyl)-1-methyl-2-oxo-but-3-ynyl]carbamate
CAS No.:1369542-96-0
Molecular Formula:C₁₆H₁₈BrNO₃
Molecular Weight:352.228
Hs Code.:

Synonyms:rac-tert-butyl N-[1-(3-bromophenyl)-1-methyl-2-oxo-but-3-ynyl]carbamate

Suppliers and Price of rac-tert-butyl N-[1-(3-bromophenyl)-1-methyl-2-oxo-but-3-ynyl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of rac-tert-butyl N-[1-(3-bromophenyl)-1-methyl-2-oxo-but-3-ynyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of rac-tert-butyl N-[1-(3-bromophenyl)-1-methyl-2-oxo-but-3-ynyl]carbamate

There total 7 articles about rac-tert-butyl N-[1-(3-bromophenyl)-1-methyl-2-oxo-but-3-ynyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1369542-95-9
rac-tert-butyl N-[1-(3-bromophenyl)-2-hydroxy-1-methyl-but-3-ynyl]carbamate

: 1369542-96-0
rac-tert-butyl N-[1-(3-bromophenyl)-1-methyl-2-oxo-but-3-ynyl]carbamate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 1.25h;

Reference yield:

: 953741-63-4
rac-2-amino-2-(3-bromo-phenyl)-propionitrile

: 1369542-96-0
rac-tert-butyl N-[1-(3-bromophenyl)-1-methyl-2-oxo-but-3-ynyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 96 h / Reflux

1.2: pH 8

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran / 15.17 h / 0 - 20 °C

3.2: pH 1 - 2 / Cooling with ice

4.1: Dess-Martin periodane / dichloromethane / 1.25 h / 0 - 20 °C

5.1: tetrahydrofuran / 0.75 h / 0 - 20 °C / Inert atmosphere

6.1: Dess-Martin periodane / dichloromethane / 1.25 h / 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1369542-96-0
rac-tert-butyl N-[1-(3-bromophenyl)-1-methyl-2-oxo-but-3-ynyl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonia; ammonium chloride / methanol / 96 h / 20 °C

2.1: hydrogenchloride / 96 h / Reflux

2.2: pH 8

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran / 15.17 h / 0 - 20 °C

4.2: pH 1 - 2 / Cooling with ice

5.1: Dess-Martin periodane / dichloromethane / 1.25 h / 0 - 20 °C

6.1: tetrahydrofuran / 0.75 h / 0 - 20 °C / Inert atmosphere

7.1: Dess-Martin periodane / dichloromethane / 1.25 h / 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; ammonia; sodium hydrogencarbonate; ammonium chloride; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane;