(2R,3S)-3-Benzyloxy-2-(tert-butoxycarbonyl-methyl-amino)-butyric acid benzyl ester

Base Information

Chemical Name:(2R,3S)-3-Benzyloxy-2-(tert-butoxycarbonyl-methyl-amino)-butyric acid benzyl ester
CAS No.:474085-54-6
Molecular Formula:C₂₄H₃₁NO₅
Molecular Weight:413.514
Hs Code.:

Synonyms:(2R,3S)-3-Benzyloxy-2-(tert-butoxycarbonyl-methyl-amino)-butyric acid benzyl ester

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Chemical Property of (2R,3S)-3-Benzyloxy-2-(tert-butoxycarbonyl-methyl-amino)-butyric acid benzyl ester

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Technology Process of (2R,3S)-3-Benzyloxy-2-(tert-butoxycarbonyl-methyl-amino)-butyric acid benzyl ester

There total 2 articles about (2R,3S)-3-Benzyloxy-2-(tert-butoxycarbonyl-methyl-amino)-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 100-39-0
benzyl bromide

: 226067-37-4
(2R,3S)-3-benzyloxy-2-[tert-butoxycarbonyl-(methyl)-amino]-butanoic acid

: 474085-54-6
(2R,3S)-3-Benzyloxy-2-(tert-butoxycarbonyl-methyl-amino)-butyric acid benzyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/ja0206700

Reference yield:

: 69355-99-3
Boc-O-benzyl-D-threonine

: 474085-54-6
(2R,3S)-3-Benzyloxy-2-(tert-butoxycarbonyl-methyl-amino)-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / NaH / tetrahydrofuran; dimethylformamide / 17 h / 0 - 20 °C

2: 80 percent / K₂CO₃ / dimethylformamide

With sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja0206700