Technology Process of 7-(benzyloxy)-8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one
There total 6 articles about 7-(benzyloxy)-8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(4-(benzyloxy)-3-methoxyphenoxy)butanoic acid;
With
pyridine; 1,3,5-trichloro-2,4,6-triazine;
In
dichloromethane;
at 0 - 20 ℃;
for 4.5h;
With
aluminum (III) chloride;
In
dichloromethane;
at -60 - 0 ℃;
for 75.12h;
DOI:10.1002/ejoc.201400004
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: boric acid; dihydrogen peroxide / sulfuric acid; tetrahydrofuran; water / 5 h / 20 °C
2.1: potassium carbonate; potassium iodide / acetone / 24 h / 60 °C
3.1: lithium hydroxide / tetrahydrofuran; water / 20 h / 60 °C / Cooling with ice
4.1: pyridine; 1,3,5-trichloro-2,4,6-triazine / dichloromethane / 4.5 h / 0 - 20 °C
4.2: 75.12 h / -60 - 0 °C
With
pyridine; 1,3,5-trichloro-2,4,6-triazine; dihydrogen peroxide; boric acid; potassium carbonate; potassium iodide; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; sulfuric acid; water; acetone;
1.1: |Dakin Phenol Oxidation / 4.2: |Friedel-Crafts Acylation;
DOI:10.1002/ejoc.201400004
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate; potassium iodide / acetone / 24 h / 60 °C
2.1: lithium hydroxide / tetrahydrofuran; water / 20 h / 60 °C / Cooling with ice
3.1: pyridine; 1,3,5-trichloro-2,4,6-triazine / dichloromethane / 4.5 h / 0 - 20 °C
3.2: 75.12 h / -60 - 0 °C
With
pyridine; 1,3,5-trichloro-2,4,6-triazine; potassium carbonate; potassium iodide; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; acetone;
3.2: |Friedel-Crafts Acylation;
DOI:10.1002/ejoc.201400004
