(+)-2-Methyl-1-butanol

Base Information

• Chemical Name: (+)-2-Methyl-1-butanol
• CAS No.: 616-16-0
• Molecular Formula: C5H12O
• Molecular Weight: 88.1497
• UNII: 1O91KQ00JS
• DSSTox Substance ID: DTXSID901044400
• Nikkaji Number: J9.248G
• Wikidata: Q27122154
• Metabolomics Workbench ID: 3192
• Mol file: 616-16-0.mol

Synonyms:616-16-0;(R)-2-METHYLBUTANOL;(+)-2-Methyl-1-butanol;(2R)-2-methylbutan-1-ol;(R)-2-methylbutan-1-ol;2-Methyl-1-butanol, (+)-;2R-Methylbutan-1-ol;(+)-(R)-2-Methyl-1-butanol;2-Methyl-1-butanol (+)-form [MI];UNII-1O91KQ00JS;1O91KQ00JS;(r)-2-methyl-1-butanol;CHEBI:50624;DTXSID901044400;LMFA05000102;MFCD00067263;AKOS006274108;EN300-218251;Q27122154

Chemical Property of (+)-2-Methyl-1-butanol

Chemical Property:

• Refractive Index: 1.4037
• Boiling Point: 129 ºC
• PKA: 15.24±0.10(Predicted)
• Flash Point: 43 ºC
• PSA: 20.23000
• Density: 0.809
• LogP: 1.02480
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 88.088815002
• Heavy Atom Count: 6
• Complexity: 27.1

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)CO
• Isomeric SMILES: CC[C@@H](C)CO

Technology Process of (+)-2-Methyl-1-butanol

There total 57 articles about (+)-2-Methyl-1-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-2-methylbutyric acid (32231-50-8) → (R)-2-Methyl-1-butanol (616-16-0)

Guidance literature:

(R)-2-methylbutyric acid; With lithium aluminium tetrahydride; In diethyl ether; at 0 - 5 ℃; for 1h;

With hydrogenchloride; water; In diethyl ether; Cooling with ice;

DOI:10.1016/j.tet.2009.02.064

Reference yield: 100.0%

(R)-(-)-2-methyl-1-(tetrahydro-2-pyranyloxy)-butan-1-ol → (R)-2-Methyl-1-butanol (616-16-0)

Guidance literature:

With Amberlyst^(R); In methanol; at 45 ℃; for 0.666667h;

DOI:10.1081/SCC-100107019

Reference yield: 95.0%

(R)-2-methyl-1-(2-tetrahydropyranyloxy)butane (130856-00-7) → (R)-2-Methyl-1-butanol (616-16-0)

Guidance literature:

With pyridinium p-toluenesulfonate; In ethanol; for 12h; Ambient temperature;

upstream raw materials:

2-Methylbutyraldehyde

(+/-)-2-methyl-1-butanol

(R)-2-methylbutyric acid

dichloromethane

Downstream raw materials:

(+)-1-bromo-2-methylbutane

(S)-1-chloro-2-methyl-butane

(-)-2-methylbutanal

(R)-2-methyl-1-butanol 4-methylbenzenesulfonate

Refernces

• 1、 Sasaerila, Yorianta,Gries, Regine,Gries, Gerhard,Khaskin, Grigori,King, Skip,Chor Boo, Teo. "Decadienoates: Sex pheromone components of nettle caterpillars Darna trima and D. bradleyi". . p. 1969 - 1981. Retrieved 2000.
• 2、 Sun, Zhi-Feng,Zhang, Tao,Liu, Jinyang,Du, Zhen-Ting,Zheng, Huaiji. "Asymmetric total synthesis of four stereoisomers of the sex pheromone of the western corn rootworm". . . Retrieved 2018/03/30.
• 3、 Yoshida, Yoshiaki,Mawatari, Yasuteru,Sasaki, Takahiro,Hiraoki, Toshifumi,Wagner, Manfred,Müllen, Klaus,Tabata, Masayoshi. "Strictly Alternating Sequences When Copolymerizing Racemic and Chiral Acetylene Monomers with an Organo-Rhodium Catalyst". . p. 1291 - 1301. Retrieved 2017/03/09.