2,6-DIFLUOROMANDELIC ACID

Base Information

• Chemical Name: 2,6-DIFLUOROMANDELIC ACID
• CAS No.: 207981-50-8
• Molecular Formula: C8H6F2O3
• Molecular Weight: 188.131
• Hs Code.: 2918199090
• Mol file: 207981-50-8.mol

Synonyms:(2,6-Difluorophenyl)(hydroxy)acetic acid;2,6-DIFLUOROMANDELIC ACID;alpha-Hydroxy-2,6-difluorophenylacetic acid;2,6-Difluoromandelic acid, tech.;à-hydroxy-2,6-difluorophenylacetic acid;2,6-Difluoromandelicacid,tech.90%;2,6-Difluoromandelic acid 90%;2-(2,6-difluorophenyl)-2-hydroxyacetic acid

Chemical Property of 2,6-DIFLUOROMANDELIC ACID

Chemical Property:

• Vapor Pressure: 0.000539mmHg at 25°C
• Melting Point: 142-145°C
• Refractive Index: 1.542
• Boiling Point: 299.258 °C at 760 mmHg
• PKA: 3.24±0.10(Predicted)
• Flash Point: 134.787 °C
• PSA: 57.53000
• Density: 1.523 g/cm³
• LogP: 1.08280

Purity/Quality:

99% ^*data from raw suppliers

2,6-DifluoromandelicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DIFLUOROMANDELIC ACID

There total 10 articles about 2,6-DIFLUOROMANDELIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.1%

2-hydroxy-2-(2,6-difluorophenyl)acetonitrile → 2-hydroxy-2-(2,6-difluorophenyl)acetic acid (207981-50-8)

Guidance literature:

With hydrogenchloride; In water; at 80 ℃; for 7h;

Reference yield:

2-Trifluoromethylbenzaldehyde (447-61-0) → 2-hydroxy-2-(2,6-difluorophenyl)acetic acid (207981-50-8) + 2-(trifluoromethyl)mandelic acid (339-93-5)

Guidance literature:

Reference yield:

perfluorobenzaldehyde (653-37-2) → 2-hydroxy-2-(2,6-difluorophenyl)acetic acid (207981-50-8) + (pentafluorophenyl)glycolic acid (652-24-4)

Guidance literature:

upstream raw materials:

4-cyanobenzaldehyde

2-Trifluoromethylbenzaldehyde

trimethylsilyl cyanide

2,6-difluorobenzaldehyde

Downstream raw materials:

3-(2,6-difluorophenyl)-5-hydroxy-5-methyl-4-phenyl-2(5H)-furanone

4-(2,6-difluorophenyl)-6-methyl-5-phenyl-2H-pyridazine-3-one

2-(2,6-difluorophenyl)-2-methoxyacetic acid

Refernces

• 1、 -. "Anti-viral compounds". . . Retrieved 2008/06/13.