(R)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-succinic acid dibenzyl ester

Base Information

Chemical Name:(R)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-succinic acid dibenzyl ester
CAS No.:499775-48-3
Molecular Formula:C₂₈H₃₅N₃O₈
Molecular Weight:541.601
Hs Code.:

Synonyms:(R)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-succinic acid dibenzyl ester

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Chemical Property of (R)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-succinic acid dibenzyl ester

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Technology Process of (R)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-succinic acid dibenzyl ester

There total 1 articles about (R)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-succinic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 61348-28-5
(2R)-5-amino-2-(tert-butoxycarbonylamino)-5-oxo-pentanoic acid

: D-aspartic acid dibenzyl ester TFA salt

: 499775-48-3
(R)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-succinic acid dibenzyl ester

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; In N,N-dimethyl-formamide; at -10 ℃; for 2h;
DOI:10.1016/S0040-4020(02)01021-9

Reference yield:

: 499775-48-3
(R)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-succinic acid dibenzyl ester

: 499775-23-4
3-[(2R,5R)-5-(2-Benzyloxycarbonylamino-ethyl)-3,6-dioxo-piperazin-2-yl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dimethylformamide; H₂O / 3 h

2: 82 percent / N-methylmorpholine / acetonitrile / 0 - 20 °C

3: acetic acid / 2 h / 20 °C

4: N-methylmorpholine; acetic acid / butan-2-ol / Heating

With 4-methyl-morpholine; pyridine; acetic acid; In water; N,N-dimethyl-formamide; acetonitrile; iso-butanol;
DOI:10.1016/S0040-4020(02)01021-9

Reference yield:

: 499775-48-3
(R)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-succinic acid dibenzyl ester

: 499775-44-9
(R)-2-((R)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-pentanedioic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dimethylformamide; H₂O / 3 h

2: 82 percent / N-methylmorpholine / acetonitrile / 0 - 20 °C

With 4-methyl-morpholine; pyridine; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(02)01021-9