(R)-2-((R)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-pentanedioic acid dibenzyl ester

Base Information

Chemical Name:(R)-2-((R)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-pentanedioic acid dibenzyl ester
CAS No.:499775-44-9
Molecular Formula:C₃₆H₄₃N₃O₉
Molecular Weight:661.752
Hs Code.:

Synonyms:(R)-2-((R)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-pentanedioic acid dibenzyl ester

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Chemical Property of (R)-2-((R)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-pentanedioic acid dibenzyl ester

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Technology Process of (R)-2-((R)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-pentanedioic acid dibenzyl ester

There total 2 articles about (R)-2-((R)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-pentanedioic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: (R)-2-((R)-4-Amino-2-tert-butoxycarbonylamino-butyrylamino)-succinic acid dibenzyl ester; compound with trifluoro-acetic acid

: 499775-44-9
(R)-2-((R)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-pentanedioic acid dibenzyl ester

Guidance literature:: With 4-methyl-morpholine; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/S0040-4020(02)01021-9

Reference yield:

: 499775-48-3
(R)-2-((R)-2-tert-Butoxycarbonylamino-4-carbamoyl-butyrylamino)-succinic acid dibenzyl ester

: 499775-44-9
(R)-2-((R)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-pentanedioic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dimethylformamide; H₂O / 3 h

2: 82 percent / N-methylmorpholine / acetonitrile / 0 - 20 °C

With 4-methyl-morpholine; pyridine; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4020(02)01021-9

Reference yield:

: 499775-44-9
(R)-2-((R)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-pentanedioic acid dibenzyl ester

: 499775-22-3
3-[(2S,5R)-5-(2-Benzyloxycarbonylamino-ethyl)-3,6-dioxo-piperazin-2-yl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 2 h / 20 °C

2: N-methylmorpholine; acetic acid / butan-2-ol / Heating

With 4-methyl-morpholine; acetic acid; In iso-butanol;
DOI:10.1016/S0040-4020(02)01021-9