3-[1-(Cyclopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5,tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl]-indazole-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 3-[1-(Cyclopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5,tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl]-indazole-1-carboxylic acid tert-butyl ester
• CAS No.: 174180-97-3
• Molecular Formula: C₃₉H₃₇N₅O₅
• Molecular Weight: 655.753
• Mol file: 174180-97-3.mol

Synonyms:3-[1-(Cyclopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5,tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl]-indazole-1-carboxylic acid tert-butyl ester

Chemical Property of 3-[1-(Cyclopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5,tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl]-indazole-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[1-(Cyclopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5,tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl]-indazole-1-carboxylic acid tert-butyl ester

There total 10 articles about 3-[1-(Cyclopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5,tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl]-indazole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-2-propanyl 3-(bromomethyl)-1H-indazole-1-carboxylate (174180-42-8) + N-Cyclopropyl-2-(2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-phenyl-acetamide (174180-99-5) → 3-[1-(Cyclopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5,tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl]-indazole-1-carboxylic acid tert-butyl ester (174180-97-3)

Guidance literature:

With sodium hexamethyldisilazane; sodium hydride; Multistep reaction; 1.) DMF, THF, 0 deg C, 2.) DMF, THF, RT, 2 h;

DOI:10.1021/jm970265x

Reference yield:

2-nitro-N-phenylaniline (119-75-5) → 3-[1-(Cyclopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5,tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl]-indazole-1-carboxylic acid tert-butyl ester (174180-97-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 110.6 g / toluene / 2 h / 80 °C

2: 43.7 g / H₂ / 10percent Pd/C / ethanol; ethyl acetate / 7 h

3: 2.75 g / NaOEt / ethanol / 1 h / Ambient temperature

4: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 18 h

5: 1.) NaH, NaN(TMS)2 / 1.) DMF, THF, 0 deg C, 2.) DMF, THF, RT, 2 h

With hydrogen; sodium ethanolate; sodium hexamethyldisilazane; sodium hydride; palladium on activated charcoal; In ethanol; ethyl acetate; toluene;

DOI:10.1021/jm970265x

Reference yield:

N-(2-nitrophenyl)-N-phenylmalonamic acid methyl ester (174181-40-9) → 3-[1-(Cyclopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5,tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl]-indazole-1-carboxylic acid tert-butyl ester (174180-97-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 43.7 g / H₂ / 10percent Pd/C / ethanol; ethyl acetate / 7 h

2: 2.75 g / NaOEt / ethanol / 1 h / Ambient temperature

3: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 18 h

4: 1.) NaH, NaN(TMS)2 / 1.) DMF, THF, 0 deg C, 2.) DMF, THF, RT, 2 h

With hydrogen; sodium ethanolate; sodium hexamethyldisilazane; sodium hydride; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1021/jm970265x

upstream raw materials:

2-methyl-2-propanyl 3-(bromomethyl)-1H-indazole-1-carboxylate

N-Cyclopropyl-2-(2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-phenyl-acetamide

di-tert-butyl dicarbonate

2'-Fluoroacetophenone