methyl 6-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinate

Base Information

Chemical Name:methyl 6-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinate
CAS No.:1355011-31-2
Molecular Formula:C₂₁H₂₆F₃NO₄Si
Molecular Weight:441.522
Hs Code.:

Synonyms:methyl 6-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinate

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Chemical Property of methyl 6-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinate

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Technology Process of methyl 6-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinate

There total 6 articles about methyl 6-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1355011-30-1
methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate

: 86864-60-0
2-(tert-butyldimethylsilyloxy)ethyl bromide

: 1355011-31-2
methyl 6-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

: 374633-36-0
2-bromo-3-fluoro-6-methylpyridine

: 1355011-31-2
methyl 6-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium permanganate / water / 53 h / 100 °C

2: sulfuric acid / 2 h / 20 °C

3: water; potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / tetrahydrofuran / 1 h / 80 - 100 °C / Inert atmosphere; Microwave irradiation

4: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

With potassium fluoride; potassium permanganate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; sulfuric acid; water; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 2713-34-0
3,5-difluorophenol

: 1355011-31-2
methyl 6-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)-5-fluoropicolinate

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 0 °C

2: n-butyllithium / tetrahydrofuran / 1 h / -78 - -65 °C / Inert atmosphere

3: water; potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / tetrahydrofuran / 1 h / 80 - 100 °C / Inert atmosphere; Microwave irradiation

4: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

With 1H-imidazole; potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; tri-tert-butyl phosphine; water; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;