(1S,8aS)-7,7-bis(2-hydroxyethyl)-N-methyl-N-(3-methyl-5-(trifluoromethyl)benzyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

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Chemical Name:(1S,8aS)-7,7-bis(2-hydroxyethyl)-N-methyl-N-(3-methyl-5-(trifluoromethyl)benzyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide
CAS No.:1453068-90-0
Molecular Formula:C₂₉H₃₆F₃N₃O₄
Molecular Weight:547.618
Hs Code.:

Synonyms:(1S,8aS)-7,7-bis(2-hydroxyethyl)-N-methyl-N-(3-methyl-5-(trifluoromethyl)benzyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

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Chemical Property of (1S,8aS)-7,7-bis(2-hydroxyethyl)-N-methyl-N-(3-methyl-5-(trifluoromethyl)benzyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

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Technology Process of (1S,8aS)-7,7-bis(2-hydroxyethyl)-N-methyl-N-(3-methyl-5-(trifluoromethyl)benzyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

There total 10 articles about (1S,8aS)-7,7-bis(2-hydroxyethyl)-N-methyl-N-(3-methyl-5-(trifluoromethyl)benzyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.3%

: 1453069-69-6
(1S,8aS)-7,7-diallyl-N-methyl-N-(3-methyl-5-(trifluoromethyl)benzyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

: 1453068-90-0
(1S,8aS)-7,7-bis(2-hydroxyethyl)-N-methyl-N-(3-methyl-5-(trifluoromethyl)benzyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: (1S,8aS)-7,7-diallyl-N-methyl-N-(3-methyl-5-(trifluoromethyl)benzyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide; With oxygen; ozone; In dichloromethane; at -78 ℃;

With sodium tetrahydroborate; In dichloromethane; at -78 - 20 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1228573-50-9
N-[2-(benzyloxycarbonylamino)ethyl]pent-4-ynamide

: 1453068-90-0
(1S,8aS)-7,7-bis(2-hydroxyethyl)-N-methyl-N-(3-methyl-5-(trifluoromethyl)benzyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 25 °C / Inert atmosphere

2.1: bis-[(trifluoroacetoxy)iodo]benzene / 2,2,2-trifluoroethanol / 3 h / 0 °C

3.1: hydrogenchloride; 5%-palladium/activated carbon; hydrogen / methanol; water / 30 h / 3800.26 Torr

4.1: hydrogenchloride / diethyl ether / 0.58 h / 20 °C

5.1: dimethyl amine / ethanol / Resolution of racemate

6.1: triethylamine; dmap / dichloromethane / 40 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

7.2: 2.5 h / -78 - -30 °C

8.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

9.1: triethylamine; dmap / ethyl acetate / 1.5 h / 0 °C

9.2: 48 h / 50 °C

10.1: ozone; oxygen / dichloromethane / -78 °C

10.2: 20 h / -78 - 20 °C / Inert atmosphere

With hydrogenchloride; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 5%-palladium/activated carbon; hydrogen; oxygen; ozone; dimethyl amine; triethylamine; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; 2,2,2-trifluoroethanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1453069-32-3
benzyl N-{2-[5-(2-methylphenyl)pent-4-ynamido]ethyl}carbamate

: 1453068-90-0
(1S,8aS)-7,7-bis(2-hydroxyethyl)-N-methyl-N-(3-methyl-5-(trifluoromethyl)benzyl)-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: bis-[(trifluoroacetoxy)iodo]benzene / 2,2,2-trifluoroethanol / 3 h / 0 °C

2.1: hydrogenchloride; 5%-palladium/activated carbon; hydrogen / methanol; water / 30 h / 3800.26 Torr

3.1: hydrogenchloride / diethyl ether / 0.58 h / 20 °C

4.1: dimethyl amine / ethanol / Resolution of racemate

5.1: triethylamine; dmap / dichloromethane / 40 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

6.2: 2.5 h / -78 - -30 °C

7.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

8.1: triethylamine; dmap / ethyl acetate / 1.5 h / 0 °C

8.2: 48 h / 50 °C

9.1: ozone; oxygen / dichloromethane / -78 °C

9.2: 20 h / -78 - 20 °C / Inert atmosphere

With hydrogenchloride; dmap; 5%-palladium/activated carbon; hydrogen; oxygen; ozone; dimethyl amine; triethylamine; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; 2,2,2-trifluoroethanol; water; ethyl acetate;