1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-thiophen-2-ylmethyl]-4-(2-isopropoxy-phenyl)-piperazine

Base Information

• Chemical Name: 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-thiophen-2-ylmethyl]-4-(2-isopropoxy-phenyl)-piperazine
• CAS No.: 223254-21-5
• Molecular Formula: C₃₅H₄₄N₂O₂SSi
• Molecular Weight: 584.898
• Mol file: 223254-21-5.mol

Synonyms:1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-thiophen-2-ylmethyl]-4-(2-isopropoxy-phenyl)-piperazine

Chemical Property of 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-thiophen-2-ylmethyl]-4-(2-isopropoxy-phenyl)-piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-thiophen-2-ylmethyl]-4-(2-isopropoxy-phenyl)-piperazine

There total 4 articles about 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-thiophen-2-ylmethyl]-4-(2-isopropoxy-phenyl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(1-methylethoxy)phenyl-1-piperazine (54013-91-1) + 4-((tert-butyldiphenylsilyloxy)methyl)thiophene-2-carbaldehyde (223254-19-1) → 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-thiophen-2-ylmethyl]-4-(2-isopropoxy-phenyl)-piperazine (223254-21-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/S0960-894X(02)00347-5

Reference yield:

3-hydroxymethyl-thiophene (71637-34-8) → 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-thiophen-2-ylmethyl]-4-(2-isopropoxy-phenyl)-piperazine (223254-21-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 91 percent / imidazole / dimethylformamide / 24 h / 20 °C

2.1: tBuLi / tetrahydrofuran / 1 h / -78 °C

2.2: 69 percent / tetrahydrofuran / 6 h

3.1: 100 percent / NaBH(OAc)3; AcOH / CH₂Cl₂ / 5 h / 20 °C

With 1H-imidazole; tert.-butyl lithium; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00347-5

Reference yield:

tert-butyldiphenyl(thiophen-3-ylmethoxy)silane (125849-86-7) → 1-[4-(tert-butyl-diphenyl-silanyloxymethyl)-thiophen-2-ylmethyl]-4-(2-isopropoxy-phenyl)-piperazine (223254-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tBuLi / tetrahydrofuran / 1 h / -78 °C

1.2: 69 percent / tetrahydrofuran / 6 h

2.1: 100 percent / NaBH(OAc)3; AcOH / CH₂Cl₂ / 5 h / 20 °C

With tert.-butyl lithium; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(02)00347-5

upstream raw materials:

2-(1-methylethoxy)phenyl-1-piperazine

4-((tert-butyldiphenylsilyloxy)methyl)thiophene-2-carbaldehyde

3-hydroxymethyl-thiophene

tert-butyldiphenyl(thiophen-3-ylmethoxy)silane

Downstream raw materials:

{5-[4-(2-isopropoxy-phenyl)-piperazin-1-ylmethyl]-thiophen-3-yl}-methanol