3-BROMO-2-FLUORO-6-PICOLINE

Base Information

• Chemical Name: 3-BROMO-2-FLUORO-6-PICOLINE
• CAS No.: 375368-78-8
• Molecular Formula: C₆H₅BrFN
• Molecular Weight: 190.015
• Hs Code.: 2933399090
• Mol file: 375368-78-8.mol

Synonyms:3-Bromo-2-fluoro-6-methylpyridine;2-Fluoro-3-Bromo-6-Methylpyridine;

Chemical Property of 3-BROMO-2-FLUORO-6-PICOLINE

Chemical Property:

• Vapor Pressure: 0.625mmHg at 25°C
• Refractive Index: 1.529
• Boiling Point: 194.2 °C at 760 mmHg
• PKA: -2.07±0.10(Predicted)
• Flash Point: 71.2 °C
• PSA: 12.89000
• Density: 1.592 g/cm³
• LogP: 2.29160
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-Bromo-2-fluoro-6-picoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-2-FLUORO-6-PICOLINE

There total 1 articles about 3-BROMO-2-FLUORO-6-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

→ 3-bromo-2-fluoro-6-methyl-pyridine (375368-78-8)

Guidance literature:

With potassium nitrite; pyridine hydrogenfluoride; at -20 - 20 ℃; for 4h;

Reference yield: 84.0%

3-bromo-2-fluoro-6-methyl-pyridine (375368-78-8) + benzyl alcohol (100-51-6,185532-71-2) → 2-benzyloxy-3-bromo-6-methyl-pyridine (1206774-24-4)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 25 ℃; for 13h;

Reference yield: 53.0%

3-bromo-2-fluoro-6-methyl-pyridine (375368-78-8) + (4aR,8aS)-6-(3-(4-hydroxyphenyl)azetidine-1-carbonyl)hexahydro-2H-pyrido[4,3-b][1,4]oxazin-3(4H)-one → (4aR,8aS)-6-[3-[4-[(3-Bromo-6-methyl-2-pyridyl)oxy]phenyl]azetidine-1-carbonyl]-4,4a,5,7,8,8a-hexahydropyrido[4,3-b][1,4]oxazin-3-one

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 50 ℃; for 12h; Inert atmosphere;

Downstream raw materials:

3-bromo-6-methyl-5-nitro-pyridin-2-ol

2-benzyloxy-3-bromo-6-methyl-pyridine

Refernces