3-BROMO-2-HYDROXY-5-NITRO-6-PICOLINE

Base Information

• Chemical Name: 3-BROMO-2-HYDROXY-5-NITRO-6-PICOLINE
• CAS No.: 874493-25-1
• Molecular Formula: C6H5BrN2O3
• Molecular Weight: 233.021
• Hs Code.: 2933399990
• Mol file: 874493-25-1.mol

Synonyms:3-BROMO-2-HYDROXY-5-NITRO-6-PICOLINE;3-BroMo-6-Methyl-5-nitropyridin-2-ol;3-Bromo-6-methyl-5-nitro-2(1H)-pyridinone;3-Bromo-6-methyl-5-nitro-2-pyridinol

Chemical Property of 3-BROMO-2-HYDROXY-5-NITRO-6-PICOLINE

Chemical Property:

• Melting Point: 261℃ (dec.)
• Density: 1.84
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-6-methyl-5-nitropyridin-2-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-2-HYDROXY-5-NITRO-6-PICOLINE

There total 10 articles about 3-BROMO-2-HYDROXY-5-NITRO-6-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-bromo-2-hydroxy-6-methylpyridine (374633-33-7) → 3-bromo-6-methyl-5-nitro-pyridin-2-ol (874493-25-1)

Guidance literature:

With nitric acid; In water; at 20 ℃; for 3.5h;

Reference yield: 60.9%

6-methyl-5-nitropyridin-2-ol (28489-45-4) → 3-bromo-6-methyl-5-nitro-pyridin-2-ol (874493-25-1)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 67 ℃; Inert atmosphere; Cooling with ice;

Reference yield: 58.9%

2-benzyloxy-3-bromo-6-methyl-pyridine (1206774-24-4) → 3-bromo-6-methyl-5-nitro-pyridin-2-ol (874493-25-1)

Guidance literature:

With nitric acid; at 0 - 25 ℃; for 12h;

upstream raw materials:

6-methyl-5-nitropyridin-2-ol

2-amino-3-bromo-6-methyl-5-nitropyridine

α-picoline

2-Amino-6-methylpyridine

Downstream raw materials:

3-bromo-2-chloro-6-methyl-5-nitropyridine