4-amino-5-(2-(4-fluorophenyl)-6-fluoroquinolin-4-yl)-4H-1,2,4-triazole-3-thiol

Base Information

Chemical Name:4-amino-5-(2-(4-fluorophenyl)-6-fluoroquinolin-4-yl)-4H-1,2,4-triazole-3-thiol
CAS No.:1596354-74-3
Molecular Formula:C₁₇H₁₁F₂N₅S
Molecular Weight:355.371
Hs Code.:

Synonyms:4-amino-5-(2-(4-fluorophenyl)-6-fluoroquinolin-4-yl)-4H-1,2,4-triazole-3-thiol

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Chemical Property of 4-amino-5-(2-(4-fluorophenyl)-6-fluoroquinolin-4-yl)-4H-1,2,4-triazole-3-thiol

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Technology Process of 4-amino-5-(2-(4-fluorophenyl)-6-fluoroquinolin-4-yl)-4H-1,2,4-triazole-3-thiol

There total 6 articles about 4-amino-5-(2-(4-fluorophenyl)-6-fluoroquinolin-4-yl)-4H-1,2,4-triazole-3-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1306588-48-6
5-(2-(4-fluorophenyl)-6-fluoro-quinolin-4-yl)-1,3,4-oxadiazole-2-thiol

: 1596354-74-3
4-amino-5-(2-(4-fluorophenyl)-6-fluoroquinolin-4-yl)-4H-1,2,4-triazole-3-thiol

Guidance literature:: With hydrazine hydrate; In 1,4-dioxane; for 7h; Reflux;
DOI:10.1016/j.jfluchem.2014.02.012

Reference yield:

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 1596354-74-3
4-amino-5-(2-(4-fluorophenyl)-6-fluoroquinolin-4-yl)-4H-1,2,4-triazole-3-thiol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol / 18 h / Reflux

2.1: potassium carbonate / acetone / 5 h / Reflux

3.1: hydrazine hydrate / ethanol / 7 h / Reflux

4.1: potassium hydroxide / ethanol / 1 h

4.2: 8 h / Reflux

5.1: hydrazine hydrate / 1,4-dioxane / 7 h / Reflux

With potassium carbonate; hydrazine hydrate; potassium hydroxide; In 1,4-dioxane; ethanol; acetone; 1.1: |Pfitzinger Quinoline Synthesis;
DOI:10.1016/j.jfluchem.2014.02.012

Reference yield:

: 1596354-59-4
methyl 6-fluoro-2-(4-fluorophenyl)quinoline-4-carboxylate

: 1596354-74-3
4-amino-5-(2-(4-fluorophenyl)-6-fluoroquinolin-4-yl)-4H-1,2,4-triazole-3-thiol

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / 7 h / Reflux

2.1: potassium hydroxide / ethanol / 1 h

2.2: 8 h / Reflux

3.1: hydrazine hydrate / 1,4-dioxane / 7 h / Reflux

With hydrazine hydrate; potassium hydroxide; In 1,4-dioxane; ethanol;
DOI:10.1016/j.jfluchem.2014.02.012