cyclohexylmethyl 1-(2,4-dimethyoxybenzyl)-4-(3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:cyclohexylmethyl 1-(2,4-dimethyoxybenzyl)-4-(3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:1224680-48-1
Molecular Formula:C₂₉H₃₆N₂O₆
Molecular Weight:508.615
Hs Code.:

Synonyms:cyclohexylmethyl 1-(2,4-dimethyoxybenzyl)-4-(3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Chemical Property of cyclohexylmethyl 1-(2,4-dimethyoxybenzyl)-4-(3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Technology Process of cyclohexylmethyl 1-(2,4-dimethyoxybenzyl)-4-(3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 3 articles about cyclohexylmethyl 1-(2,4-dimethyoxybenzyl)-4-(3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 296277-76-4
1-(2,4-dimethoxybenzyl)urea

: 5396-89-4
benzyl acetoacetate

: 100-83-4
meta-hydroxybenzaldehyde

: 1224680-48-1
cyclohexylmethyl 1-(2,4-dimethyoxybenzyl)-4-(3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With acetic acid; In tetrahydrofuran; at 90 ℃; for 12h; Inert atmosphere;

Reference yield:

: 296277-76-4
1-(2,4-dimethoxybenzyl)urea

: 100303-76-2
cyclohexylmethyl 3-oxobutanoate

: 591-31-1
3-methoxy-benzaldehyde

: 1224680-48-1
cyclohexylmethyl 1-(2,4-dimethyoxybenzyl)-4-(3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With boron trifluoride diethyl etherate; copper(l) chloride; In tetrahydrofuran; acetic acid; at 65 ℃; for 12h;
DOI:10.1016/j.bmcl.2011.12.090

Reference yield:

: 20781-21-9
2,4-dimethoxybenzylamine hydrochloride

: 1224680-48-1
cyclohexylmethyl 1-(2,4-dimethyoxybenzyl)-4-(3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / Reflux

2: boron trifluoride diethyl etherate; copper(l) chloride / tetrahydrofuran; acetic acid / 12 h / 65 °C

With hydrogenchloride; boron trifluoride diethyl etherate; copper(l) chloride; In tetrahydrofuran; water; acetic acid; 2: Biginelli pyrimidine synthesis;
DOI:10.1016/j.bmcl.2011.12.090