Butanoic acid, 3-oxo-, cyclohexylmethyl ester

Base Information

• Chemical Name: Butanoic acid, 3-oxo-, cyclohexylmethyl ester
• CAS No.: 100303-76-2
• Molecular Formula: C11H18O3
• Molecular Weight: 198.262
• Mol file: 100303-76-2.mol

Synonyms:

Chemical Property of Butanoic acid, 3-oxo-, cyclohexylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 3-oxo-, cyclohexylmethyl ester

There total 4 articles about Butanoic acid, 3-oxo-, cyclohexylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2,2,6-trimethyl-4H-1,3-dioxin-4-one (5394-63-8) + cyclohexylmethyl alcohol (100-49-2) → cyclohexylmethyl 3-oxobutanoate (100303-76-2)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; at 150 ℃; for 2h;

DOI:10.1007/s12272-011-0902-9

Reference yield: 79.0%

4-methyleneoxetan-2-one (674-82-8,2130-41-8) + cyclohexylmethyl alcohol (100-49-2) → cyclohexylmethyl 3-oxobutanoate (100303-76-2)

Guidance literature:

With sodium hydride; at 70 - 80 ℃; for 2h;

DOI:10.1248/cpb.34.1589

Reference yield: 67.0%

→ cyclohexylmethyl 3-oxobutanoate (100303-76-2)

Guidance literature:

In toluene; at 150 ℃; for 6h;

upstream raw materials:

4-methyleneoxetan-2-one

cyclohexylmethyl alcohol

2,2,6-trimethyl-4H-1,3-dioxin-4-one

2,2,6-trimethyl-4H-1,3-dioxin-4-one

Downstream raw materials:

2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-cyclohexylmethyl ester 5-methyl ester

cyclohexylmethyl 1-(2,4-dimethyoxybenzyl)-4-(3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

cyclohexylmethyl 4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

cyclohexylmethyl 4-(2-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Refernces

• 1、 -. "NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS". Paragraph 0194; 0195; 0205. . Retrieved 2019/05/16.
• 2、 Navidpour, Latifeh,Shafaroodi, Hamed,Miri, Ramin,Dehpour, Ahmad Reza,Shafiee, Abbas. "Lipophilic 4-imidazoly-1,4-dihydropyridines: Synthesis, calcium channel antagonist activity and protection against pentylenetetrazole-induced seizure". . p. 261 - 269. Retrieved 2007/10/03.