C₁₉H₁₆ClF₃O₄

Base Information

• Chemical Name: C₁₉H₁₆ClF₃O₄
• CAS No.: 1285721-52-9
• Molecular Formula: C₁₉H₁₆ClF₃O₄
• Molecular Weight: 400.782
• Mol file: 1285721-52-9.mol

Synonyms:C₁₉H₁₆ClF₃O₄

Chemical Property of C₁₉H₁₆ClF₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of C₁₉H₁₆ClF₃O₄

There total 4 articles about C₁₉H₁₆ClF₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

[(2R,3R)-3-(4-chlorophenyl)oxiran-2-yl]methanol (104171-24-6) + R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid (20445-31-2) → C19H16ClF3O4 (1285721-52-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jo1025964

Reference yield:

4-chlorobenzaldehyde (104-88-1) → C19H16ClF3O4 (1285721-52-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; tert-butyl alcohol / 3 h / 25 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: lithium triethylborohydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 25 °C / Inert atmosphere

With dmap; lithium triethylborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;

DOI:10.1021/jo1025964

Reference yield:

C18H24ClNO3S (1285721-20-1) → C19H16ClF3O4 (1285721-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium triethylborohydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 25 °C / Inert atmosphere

With dmap; lithium triethylborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo1025964

upstream raw materials:

[(2R,3R)-3-(4-chlorophenyl)oxiran-2-yl]methanol

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

C₁₈H₂₄ClNO₃S

C₂₃H₂₆ClNO₄S