2,2-difluoro-2-bromoacetic acid isopropyl ester

Base Information

• Chemical Name: 2,2-difluoro-2-bromoacetic acid isopropyl ester
• CAS No.: 134682-34-1
• Molecular Formula: C₅H₇BrF₂O₂
• Molecular Weight: 217.01
• Mol file: 134682-34-1.mol

Synonyms:2,2-difluoro-2-bromoacetic acid isopropyl ester

Chemical Property of 2,2-difluoro-2-bromoacetic acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-difluoro-2-bromoacetic acid isopropyl ester

There total 1 articles about 2,2-difluoro-2-bromoacetic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromodifluoroacetic acid (354-08-5) + isopropyl alcohol (67-63-0,8013-70-5) → 2,2-difluoro-2-bromoacetic acid isopropyl ester (134682-34-1)

Guidance literature:

bromodifluoroacetic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

isopropyl alcohol; With triethylamine; In dichloromethane; at 0 ℃; for 2.33h; Inert atmosphere;

DOI:10.1002/anie.201604152

Reference yield: 77.0%

2,2-difluoro-2-bromoacetic acid isopropyl ester (134682-34-1) + N-phenylhex-5-enamide (153035-39-3) → isopropyl 2,2-difluoro-8-oxo-8-(phenylamino)octanoate

Guidance literature:

With phenylsilane; sodium carbonate; nickel dichloride; In N,N-dimethyl-formamide; at 70 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.1c04346

Reference yield: 65.0%

2,2-difluoro-2-bromoacetic acid isopropyl ester (134682-34-1) + phenylacetylene (536-74-3) → (E)-2,2-Difluoro-4-phenyl-but-3-enoic acid isopropyl ester

Guidance literature:

phenylacetylene; With zirconocene hydrochloride; In tetrahydrofuran; for 0.5h;

2,2-difluoro-2-bromoacetic acid isopropyl ester; With n-butyllithium; tetrakis(triphenylphosphine)nickel⁽⁰⁾; In tetrahydrofuran; hexane; for 24h;

DOI:10.1016/S0040-4039(99)02212-1

upstream raw materials:

bromodifluoroacetic acid

isopropyl alcohol

Downstream raw materials:

(3R,4R)-isopropyl 5-(benzyloxy)-2,2-difluoro-3-hydroxy-4-(2,2,6,6-tetramethylpiperidin-1-yloxy)pentanoate

(3S,4R)-isopropyl 5-(benzyloxy)-2,2-difluoro-3-hydroxy-4-(2,2,6,6-tetramethylpiperidin-1-yloxy)pentanoate