354-08-5

Basic information

• Product Name: BROMODIFLUOROACETIC ACID
• Synonyms: RARECHEM AL BO 1034;BROMODIFLUOROACETIC ACID;Difluorobromoacetic acid;2-Bromo-2,2-difluoroethanoic acid;Acetic acid,2-bromo-2,2-difluoro-
• CAS NO: 354-08-5
• Molecular Formula: C₂HBrF₂O₂
• Molecular Weight: 174.93
• Mol File: 354-08-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 40
• Boiling Point: 134 °C
• Flash Point: 36.8 ºC
• Appearance: /
• Density: 2.178 g/cm³
• Vapor Pressure: 2.71mmHg at 25°C
• Refractive Index: 1.433
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.21±0.10(Predicted)
• CAS DataBase Reference: BROMODIFLUOROACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BROMODIFLUOROACETIC ACID(354-08-5)
• EPA Substance Registry System: BROMODIFLUOROACETIC ACID(354-08-5)

Safety Data

• Hazard Codes: C
• HazardClass: CORROSIVE
• Hazardous Substances Data: 354-08-5(Hazardous Substances Data)

Usage

General Description

Bromodifluoroacetic acid is a chemical compound with the formula BrCF2CO2H. It is a type of haloacetic acid, a group of compounds characterized by their halogen and acetic acid components. BROMODIFLUOROACETIC ACID is notable for including both bromine and fluorine atoms. It often appears as a colorless liquid and is generally used in scientific research due to its properties as a halogenated compound. The presence of bromine and fluorine atoms allows it to participate in a range of chemical reactions, making it useful in the development of various other chemical compounds. It should be handled with care due to its potential to cause harm in humans and the environment.

InChI:InChI=1/C2HBrF2O2/c3-2(4,5)1(6)7/h(H,6,7)

Upstream product

• 381-73-7 Difluoroacetic acid 
• 7726-95-6 bromine 
• 558-57-6 1,2-dibromo-1,1-dichloro-2,2-difluoroethane 
• 7757-83-7 sodium sulfite 
• 354-51-8 1,2-dibromo-1-chloro-1,2,2-trifluoroethane 
• 667-27-6 Ethyl bromodifluoroacetate 
• 759-19-3 1,2,3,4-tetrabromo-1,1,4,4-tetrafluoro-but-2-ene 
• 764-06-7 1,4-dibromo-1,1,4,4-tetrafluorobuta-2-ene 

Downstream Products

• 871503-59-2 N-(p-anisyl)-2-bromo-2,2-difluoroacetimidoyl chloride 
• 7601-98-1 (2-bromo-2,2-difluoroacetyl) 2-bromo-2,2-difluoroacetate 
• 1353883-62-1 C₁₀H₅BrClF₂N 
• 1353883-60-9 C₁₄H₁₃BrClF₂N 
• 1353883-59-6 C₁₆H₉BrClF₂N 
• 1353883-61-0 C₁₇H₁₁BrClF₂NO 
• 186828-50-2 2-(1-bromodifluoromethyl)benzo-1,3-oxazole 
• 235781-28-9 2-(1-bromodifluoromethyl)-1,3-benzo-thiazole 
• 328-03-0 2-(2,4-dichlorophenoxy)-2,2-difluoroacetic acid 

Relevant articles and documents

Continuous Process for Preparing the Difluoromethylating Reagent [(DMPU)2Zn(CF2H)2] and Improved Synthesis of the ICHF2Precursor

Complex [(DMPU)2Zn(CF2H)2] 1 is a crystalline organometallic reagent with utility in various catalytic difluoromethylation reactions under mild conditions. Unfortunately, this reagent is not commercially available and the procedure for the preparation of this air- and moisture-sensitive zinc complex has only been reported on a small scale. Herein, we report the development of a continuous process for the preparation of reagent 1 on >100 g scale by using a continuous stirred-tank reactor. The key to success is the design of a continuous reactive crystallization process in which the precipitation of the zinc complex 1 is driven by its low solubility in the reaction solvent. The improved synthesis of the iododifluoromethane precursor 2 from readily available bromodifluoroacetic acid further enables the synthesis of complex 1 on a larger scale.

REACTIONS OF PERHALOCARBONS. PART IX. CONVERSION OF PER(POLY)FLUOROALKYL HALIDES INTO THE CORRESPONDING CARBOCYCLIC ACIDS WITH A REDOX SYSTEM

The conversion of per(poly)fluoroalkylhalides into the corresponding carbocyclic acids with a redox system-(NH4)2S2O8/HCO2Na is described.The reaction provides a convenient method for the synthesis of various per(poly)fluorocarboxylic acids under mild conditions.