dimethyl (2R,2'R)-1,1'-((2S,2'S)-2,2'-(biphenyl-4,4'-diylbis(azandiyl))bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

Base Information

Chemical Name:dimethyl (2R,2'R)-1,1'-((2S,2'S)-2,2'-(biphenyl-4,4'-diylbis(azandiyl))bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate
CAS No.:1512624-39-3
Molecular Formula:C₃₆H₄₈N₆O₈
Molecular Weight:692.813
Hs Code.:

dimethyl (2R,2'R)-1,1'-((2S,2'S)-2,2'-(biphenyl-4,4'-diylbis(azandiyl))bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

Synonyms:dimethyl (2R,2'R)-1,1'-((2S,2'S)-2,2'-(biphenyl-4,4'-diylbis(azandiyl))bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

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Chemical Property of dimethyl (2R,2'R)-1,1'-((2S,2'S)-2,2'-(biphenyl-4,4'-diylbis(azandiyl))bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

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Technology Process of dimethyl (2R,2'R)-1,1'-((2S,2'S)-2,2'-(biphenyl-4,4'-diylbis(azandiyl))bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

There total 7 articles about dimethyl (2R,2'R)-1,1'-((2S,2'S)-2,2'-(biphenyl-4,4'-diylbis(azandiyl))bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 171567-86-5
(R)-2-((methoxycarbonyl)amino)-3-methylbutanoic acid

: C₂₂H₂₆N₄O₂*2C₂HF₃O₂

: 1512624-39-3
dimethyl (2R,2'R)-1,1'-((2S,2'S)-2,2'-(biphenyl-4,4'-diylbis(azandiyl))bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

Guidance literature:: With 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.25h;
DOI:10.1021/ml4003293

Reference yield: 36.0%

: 1512624-36-0
(2S,2′S)-di-tert-butyl 2,2′-(([1,1′-biphenyl]4,4′diylbis(azanediyl))bis(carbonyl))bis(pyrrolidine-1-carboxylate)

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1512624-39-3
dimethyl (2R,2'R)-1,1'-((2S,2'S)-2,2'-(biphenyl-4,4'-diylbis(azandiyl))bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

Guidance literature:: (2S,2′S)-di-tert-butyl 2,2′-(([1,1′-biphenyl]4,4′diylbis(azanediyl))bis(carbonyl))bis(pyrrolidine-1-carboxylate); With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

N-methoxycarbonyl-L-valine; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.31667h;

Reference yield:

: 92-87-5
p,p'-diaminobiphenyl

: 1512624-39-3
dimethyl (2R,2'R)-1,1'-((2S,2'S)-2,2'-(biphenyl-4,4'-diylbis(azandiyl))bis(oxomethylene)bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl)dicarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,2-dichloro-ethane / dichloromethane / 2 h / 20 °C

2: dichloromethane / 5 h / 20 °C

3: 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.25 h / 20 °C

With 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ml4003293