(2R,3E)-3-methyl-4-(2-methylthiazol-4-yl)-1-cyanobut-3-en-2-yl (1S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate

Base Information

Chemical Name:(2R,3E)-3-methyl-4-(2-methylthiazol-4-yl)-1-cyanobut-3-en-2-yl (1S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate
CAS No.:1263941-46-3
Molecular Formula:C₂₀H₁₉F₃N₂O₃S
Molecular Weight:424.444
Hs Code.:

Synonyms:(2R,3E)-3-methyl-4-(2-methylthiazol-4-yl)-1-cyanobut-3-en-2-yl (1S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate

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Chemical Property of (2R,3E)-3-methyl-4-(2-methylthiazol-4-yl)-1-cyanobut-3-en-2-yl (1S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate

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Technology Process of (2R,3E)-3-methyl-4-(2-methylthiazol-4-yl)-1-cyanobut-3-en-2-yl (1S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate

There total 3 articles about (2R,3E)-3-methyl-4-(2-methylthiazol-4-yl)-1-cyanobut-3-en-2-yl (1S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1263941-38-3
(3S,4E)-3-hydroxy-4-methyl-5-(2-methylthiazol-4-yl)pent-4-enenitrile

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 1263941-46-3
(2R,3E)-3-methyl-4-(2-methylthiazol-4-yl)-1-cyanobut-3-en-2-yl (1S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1134/S1070428010110175

Reference yield:

: C₉H₁₃NO₂S

: 1263941-46-3
(2R,3E)-3-methyl-4-(2-methylthiazol-4-yl)-1-cyanobut-3-en-2-yl (1S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 5 h / 0 - 5 °C

2: dimethyl sulfoxide / 10 h / 40 °C

3: pyridine / dichloromethane / 12 h / 20 °C

With pyridine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1134/S1070428010110175

Reference yield:

: 1263941-34-9
(2S,3E)-2-hydroxy-3-methyl-4-(2-methylthiazol-4-yl)but-3-enyl 4-methylphenylsulfonate

: 1263941-46-3
(2R,3E)-3-methyl-4-(2-methylthiazol-4-yl)-1-cyanobut-3-en-2-yl (1S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate

Guidance literature:: Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 10 h / 40 °C

2: pyridine / dichloromethane / 12 h / 20 °C

With pyridine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1134/S1070428010110175