4-chloro-2-(4-chlorobenzylthio)-5-(1,3,4-oxadiazol-2-yl)-benzenesulfonamide

Base Information

• Chemical Name: 4-chloro-2-(4-chlorobenzylthio)-5-(1,3,4-oxadiazol-2-yl)-benzenesulfonamide
• CAS No.: 1380545-57-2
• Molecular Formula: C₁₅H₁₁Cl₂N₃O₃S₂
• Molecular Weight: 416.309
• Mol file: 1380545-57-2.mol

Synonyms:4-chloro-2-(4-chlorobenzylthio)-5-(1,3,4-oxadiazol-2-yl)-benzenesulfonamide

Chemical Property of 4-chloro-2-(4-chlorobenzylthio)-5-(1,3,4-oxadiazol-2-yl)-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-2-(4-chlorobenzylthio)-5-(1,3,4-oxadiazol-2-yl)-benzenesulfonamide

There total 2 articles about 4-chloro-2-(4-chlorobenzylthio)-5-(1,3,4-oxadiazol-2-yl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2,4-dichloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide (1380545-52-7) + (4-chlorophenyl)methanethiol (6258-66-8) → 4-chloro-2-(4-chlorobenzylthio)-5-(1,3,4-oxadiazol-2-yl)-benzenesulfonamide (1380545-57-2)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In water; acetonitrile; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1007/s00706-012-0732-6

Reference yield:

2,4-dichloro-5-(carbazoyl)benzenesulfonamide (18648-15-2) → 4-chloro-2-(4-chlorobenzylthio)-5-(1,3,4-oxadiazol-2-yl)-benzenesulfonamide (1380545-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / Reflux

2: tetrabutylammomium bromide; potassium carbonate / water; acetonitrile / 24 h / 20 °C / Inert atmosphere

With tetrabutylammomium bromide; potassium carbonate; In water; acetic acid; acetonitrile;

DOI:10.1007/s00706-012-0732-6

Reference yield: 47.0%

2-thiophenylcarboxylic acid (527-72-0) + 4-chloro-2-(4-chlorobenzylthio)-5-(1,3,4-oxadiazol-2-yl)-benzenesulfonamide (1380545-57-2) → 4-chloro-2-(4-chlorobenzylthio)-5-(1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamide (1380545-65-2)

Guidance literature:

2-thiophenylcarboxylic acid; 4-chloro-2-(4-chlorobenzylthio)-5-(1,3,4-oxadiazol-2-yl)-benzenesulfonamide; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 18h;

With toluene-4-sulfonic acid; In acetonitrile;

DOI:10.1007/s00706-012-0732-6

upstream raw materials:

2,4-dichloro-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamide

(4-chlorophenyl)methanethiol

2,4-dichloro-5-(carbazoyl)benzenesulfonamide

Downstream raw materials:

4-chloro-2-(4-chlorobenzylthio)-5-(1,3,4-oxadiazol-2-yl)-N-(thien-2-ylcarbonyl)benzenesulfonamide