N-[5-(4-chloro-6-methyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-benzenesulfonamide

Base Information

Chemical Name:N-[5-(4-chloro-6-methyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-benzenesulfonamide
CAS No.:1391979-27-3
Molecular Formula:C₁₉H₁₅ClN₄O₂S
Molecular Weight:398.873
Hs Code.:

Synonyms:N-[5-(4-chloro-6-methyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-benzenesulfonamide

Suppliers and Price of N-[5-(4-chloro-6-methyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[5-(4-chloro-6-methyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[5-(4-chloro-6-methyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-benzenesulfonamide

There total 11 articles about N-[5-(4-chloro-6-methyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1391979-25-1
5-(4-chloro-6-methyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-ylamine

: 98-09-9
benzenesulfonyl chloride

: 1391979-27-3
N-[5-(4-chloro-6-methyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-benzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1391979-27-3
N-[5-(4-chloro-6-methyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 2 h / 0 - 50 °C

2.1: hydrogenchloride / water / 3 h / Reflux

3.1: ammonium chloride; iron / ethanol / 3 h / Reflux

4.1: diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 100 °C / Inert atmosphere

5.1: potassium carbonate; methanol / 3 h / 20 °C

6.1: diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / dimethyl sulfoxide / 65 °C / Inert atmosphere

7.1: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; methanol; iron; sodium hydride; potassium carbonate; ammonium chloride; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 911434-04-3
2-(5-bromo-3-nitro-pyridin-2-yl)-malonic acid diethyl ester

: 1391979-27-3
N-[5-(4-chloro-6-methyl-pyrimidin-5-ylethynyl)-2-methyl-pyridin-3-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / water / 3 h / Reflux

2: ammonium chloride; iron / ethanol / 3 h / Reflux

3: diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 100 °C / Inert atmosphere

4: potassium carbonate; methanol / 3 h / 20 °C

5: diisopropylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / dimethyl sulfoxide / 65 °C / Inert atmosphere

6: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; methanol; iron; potassium carbonate; ammonium chloride; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; dimethyl sulfoxide;