(3S,4S)-1-di-p-anisylmethyl-3-(1,1-dimethoxyethyl)-4-<(S)-1-(2-methoxyethoxymethoxy)ethyl>-2-azetidinone

Base Information

Chemical Name:(3S,4S)-1-di-p-anisylmethyl-3-(1,1-dimethoxyethyl)-4-<(S)-1-(2-methoxyethoxymethoxy)ethyl>-2-azetidinone
CAS No.:127200-95-7
Molecular Formula:C₂₈H₃₉NO₈
Molecular Weight:517.62
Hs Code.:

Synonyms:(3S,4S)-1-di-p-anisylmethyl-3-(1,1-dimethoxyethyl)-4-<(S)-1-(2-methoxyethoxymethoxy)ethyl>-2-azetidinone

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Chemical Property of (3S,4S)-1-di-p-anisylmethyl-3-(1,1-dimethoxyethyl)-4-<(S)-1-(2-methoxyethoxymethoxy)ethyl>-2-azetidinone

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Technology Process of (3S,4S)-1-di-p-anisylmethyl-3-(1,1-dimethoxyethyl)-4-<(S)-1-(2-methoxyethoxymethoxy)ethyl>-2-azetidinone

There total 12 articles about (3S,4S)-1-di-p-anisylmethyl-3-(1,1-dimethoxyethyl)-4-<(S)-1-(2-methoxyethoxymethoxy)ethyl>-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 3970-21-6
2-Methoxyethoxymethyl chloride

: 127200-96-8
(3S,4S)-1-di-p-anisylmethyl-3-(1,1-dimethoxyethyl)-4-<(S)-1-hydroxyethyl>-2-azetidinone

: 127200-95-7
(3S,4S)-1-di-p-anisylmethyl-3-(1,1-dimethoxyethyl)-4-<(S)-1-(2-methoxyethoxymethoxy)ethyl>-2-azetidinone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(01)89105-5

Reference yield:

: 90-96-0
bis(p-methoxyphenyl)methanone

: 127200-95-7
(3S,4S)-1-di-p-anisylmethyl-3-(1,1-dimethoxyethyl)-4-<(S)-1-(2-methoxyethoxymethoxy)ethyl>-2-azetidinone

Guidance literature:: Multi-step reaction with 6 steps

1: 2.) formamide, MgCl₂ / 1.) 180-190 deg C, 4 h; 2.) 180-190 deg C, 2 h

2: 8.48 g / 1M HCl / methanol / 2 h / Heating

3: 1.02 g / MgSO₄ / toluene / 1 h / 0 °C

4: 0.241 g / imidazole / CH₂Cl₂ / 69 h / -35 °C

5: 79 percent / camphorsulfonic acide / methanol / 1.5 h / Ambient temperature

6: 80 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; camphor-10-sulfonic acid; magnesium sulfate; formamide; N-ethyl-N,N-diisopropylamine; magnesium chloride; In methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)89105-5

Reference yield:

: 19293-62-0
p,p'-dimethoxybenzhydrylamine

: 127200-95-7
(3S,4S)-1-di-p-anisylmethyl-3-(1,1-dimethoxyethyl)-4-<(S)-1-(2-methoxyethoxymethoxy)ethyl>-2-azetidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.02 g / MgSO₄ / toluene / 1 h / 0 °C

2: 0.241 g / imidazole / CH₂Cl₂ / 69 h / -35 °C

3: 79 percent / camphorsulfonic acide / methanol / 1.5 h / Ambient temperature

4: 80 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 24 h / Ambient temperature

With 1H-imidazole; camphor-10-sulfonic acid; magnesium sulfate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)89105-5