(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 3,3,3-trifluoro-propyl ester

Base Information

Chemical Name:(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 3,3,3-trifluoro-propyl ester
CAS No.:1026438-73-2
Molecular Formula:C₂₇H₂₈F₃N₂O₅P
Molecular Weight:548.499
Hs Code.:

(3-benzyloxycarbamoyl-3,4-dihydro-1<i>H</i>-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 3,3,3-trifluoro-propyl ester

Synonyms:(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 3,3,3-trifluoro-propyl ester

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Chemical Property of (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 3,3,3-trifluoro-propyl ester

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Technology Process of (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 3,3,3-trifluoro-propyl ester

There total 7 articles about (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 3,3,3-trifluoro-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41220-48-8
(3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride

: 1026438-73-2
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 3,3,3-trifluoro-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / aq. sodium carbonate / dioxane / 20 °C

2: 41 percent / WSC; HOBt; triethylamine / dimethylformamide / 20 °C

3: 4.6 g / 4 N HCl / ethyl acetate / 2 h / 20 °C

4: pyridine / 0.25 h / 20 °C

5: pyridine / 20 °C

With pyridine; hydrogenchloride; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm010349c

Reference yield:

: 362477-34-7
(3R)-N-benzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

: 1026438-73-2
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 3,3,3-trifluoro-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 4.6 g / 4 N HCl / ethyl acetate / 2 h / 20 °C

2: pyridine / 0.25 h / 20 °C

3: pyridine / 20 °C

With pyridine; hydrogenchloride; In ethyl acetate;
DOI:10.1021/jm010349c

Reference yield:

: (4-methoxy-phenyl)-phosphonic acid mono-(3,3,3-trifluoro-propyl) ester

: 1026438-73-2
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 3,3,3-trifluoro-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂; DMF / Heating

2: i-Pr₂NEt / tetrahydrofuran

With thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran;
DOI:10.1016/S0960-894X(01)00796-X