1-[4-methoxyphenyl]-3-cyano-4-amino-5-[4-bromophenylaminocarbonyl]pyrazole

Base Information

Chemical Name:1-[4-methoxyphenyl]-3-cyano-4-amino-5-[4-bromophenylaminocarbonyl]pyrazole
CAS No.:280119-79-1
Molecular Formula:C₁₈H₁₄BrN₅O₂
Molecular Weight:412.245
Hs Code.:

Synonyms:1-[4-methoxyphenyl]-3-cyano-4-amino-5-[4-bromophenylaminocarbonyl]pyrazole

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Chemical Property of 1-[4-methoxyphenyl]-3-cyano-4-amino-5-[4-bromophenylaminocarbonyl]pyrazole

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Technology Process of 1-[4-methoxyphenyl]-3-cyano-4-amino-5-[4-bromophenylaminocarbonyl]pyrazole

There total 6 articles about 1-[4-methoxyphenyl]-3-cyano-4-amino-5-[4-bromophenylaminocarbonyl]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 280119-44-0
Methyl (1-[4-Methoxyphenyl]-3-cyano-4-amino)pyrazole-5-carboxylate

: 280119-79-1
1-[4-methoxyphenyl]-3-cyano-4-amino-5-[4-bromophenylaminocarbonyl]pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaNO₂; TFA / 0 °C

1.2: 75 percent / NaN₃

2.1: aq. LiOH / tetrahydrofuran

3.1: (COCl)2 / CH₂Cl₂

4.1: CH₂Cl₂

5.1: 50 percent / SnCl₂*2H₂O / propan-2-ol

With lithium hydroxide; oxalyl dichloride; trifluoroacetic acid; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2006.04.044

Reference yield:

: 4-azido-5-cyano-2-(4-methoxy-phenyl)-2H-pyrazole-3-carbonyl chloride

: 280119-79-1
1-[4-methoxyphenyl]-3-cyano-4-amino-5-[4-bromophenylaminocarbonyl]pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂

2: 50 percent / SnCl₂*2H₂O / propan-2-ol

With tin(ll) chloride; In dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2006.04.044

Reference yield:

: 280119-48-4
(1-[4-Methoxyphenyl]-3-cyano-4-azido)pyrazole-5-carboxylic acid

: 280119-79-1
1-[4-methoxyphenyl]-3-cyano-4-amino-5-[4-bromophenylaminocarbonyl]pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: (COCl)2 / CH₂Cl₂

2: CH₂Cl₂

3: 50 percent / SnCl₂*2H₂O / propan-2-ol

With oxalyl dichloride; tin(ll) chloride; In dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmcl.2006.04.044