Isoquinoline-5-sulphonyl chloride hydrochloride

Base Information

• Chemical Name: Isoquinoline-5-sulphonyl chloride hydrochloride
• CAS No.: 105627-79-0
• Molecular Formula: C9H7Cl2NO2S
• Molecular Weight: 264.132
• Hs Code.: 29334900
• Mol file: 105627-79-0.mol

Synonyms:5-Isoquinolinesulfonylchloride, hydrochloride (9CI);

Chemical Property of Isoquinoline-5-sulphonyl chloride hydrochloride

Chemical Property:

• Melting Point: 173-183°C
• PSA: 55.41000
• LogP: 4.04510
• Storage Temp.: -20°C Freezer

Purity/Quality:

99% ^*data from raw suppliers

Isoquinoline-5-sulfonylChloride,Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Isoquinoline-5-sulfonyl Chloride, Hydrochloride (cas# 105627-79-0) is a compound useful in organic synthesis.

Technology Process of Isoquinoline-5-sulphonyl chloride hydrochloride

There total 4 articles about Isoquinoline-5-sulphonyl chloride hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

isoquinoline-5-sulfonic acid (27655-40-9) → isoquinoline-5-sulfonyl chloride hydrochloride (105627-79-0)

Guidance literature:

With bis(trichloromethyl) carbonate; Triphenylphosphine oxide; In ethyl acetate; at 50 ℃; for 5h; Temperature; Solvent;

Reference yield: 80.9%

isoquinoline-5-sulfonic acid → isoquinoline-5-sulfonyl chloride hydrochloride (105627-79-0)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; for 4h; Reflux;

DOI:10.1021/jm500324g

Reference yield:

isoquinoline (119-65-3) → isoquinoline-5-sulfonyl chloride hydrochloride (105627-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 72.4 percent / oleum / 48 h / 20 °C

2: 92.4 percent / thionyl chloride / dimethylformamide / 2 h / Heating

With thionyl chloride; sulfuric acid; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2004.02.005

upstream raw materials:

isoquinoline-5-sulfonic acid

isoquinoline

Downstream raw materials:

N-(2-aminomethyl)-5-isoquinolinesulfonamide

1-benzyl-4-(isoquinoline-5-sulfonyl)piperazine-2-carboxylic acid ethyl ester

(5-isoquinolinylsulfonyl)piperazine

H-9

Refernces

• 1、 -. "Method for preparing isoquinoline hydrochloride intermediate and Rho kinase inhibitor by using BTC/Ph3PO chlorination system". Paragraph 0046-0099. . Retrieved 2020/11/23.
• 2、 -. "Preparation method of Fasudil hydrochloride". Paragraph 0032-0034; 0040; 0046. . Retrieved 2019/04/17.