Fasudil

Base Information Edit

Chemical Name:Fasudil
CAS No.:103745-39-7
Molecular Formula:C14H17N3O2S
Molecular Weight:291.374
Hs Code.:29334900
European Community (EC) Number:816-154-4
NSC Number:759827
UNII:Q0CH43PGXS
DSSTox Substance ID:DTXSID4048569
Nikkaji Number:J227.600C
Wikipedia:Fasudil
Wikidata:Q5437132
NCI Thesaurus Code:C65624
Pharos Ligand ID:PR7RKZVNN5TC
Metabolomics Workbench ID:151310
ChEMBL ID:CHEMBL38380
Mol file:103745-39-7.mol

Synonyms:1H-1,4-Diazepine,hexahydro-1-(5-isoquinolinylsulfonyl)- (9CI);1-(5-Isoquinolinesulphonyl)homopiperazine;AT 877;Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine;HA 1077;

Suppliers and Price of Fasudil

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Fasudil
100mg
$ 165.00

Sigma-Aldrich
HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem
1mg
$ 124.00

Labseeker
(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE,2HCL 95
100g
$ 923.00

DC Chemicals
Fasudil
1g
$ 350.00

CSNpharm
Fasudil
250mg
$ 67.00

Crysdot
Fasudil 98+%
250mg
$ 63.00

AvaChem
Fasudil
10g
$ 590.00

AvaChem
Fasudil
100mg
$ 49.00

AvaChem
Fasudil
1g
$ 109.00

ApexBio Technology
Fasudil
200mg
$ 70.00

Total 113 raw suppliers

Chemical Property of Fasudil Edit

Chemical Property:

Appearance/Colour:White crystalline solid
Vapor Pressure:2.55E-12mmHg at 25°C
Boiling Point:506.2 °C at 760 mmHg
PKA:9.73±0.20(Predicted)
Flash Point:259.9 °C
PSA：70.68000
Density:1.289 g/cm³
LogP:4.17030
Storage Temp.:Store at RT
Solubility.:H2O: >200 mg/mL
Water Solubility.:Soluble in water or DMSO
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:291.10414797
Heavy Atom Count:20
Complexity:421

Purity/Quality:

99% ^*data from raw suppliers

Fasudil ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
Recent ClinicalTrials:Inhibition of Rho Kinase (ROCK) With Fasudil as Disease-modifying Treatment for ALS
Recent NIPH Clinical Trials:Clinical trial of prevention for PCI-related myocardial infarction evaluating index of microvascular resistance in stable coronary artery disease. -Effect of Fasudil, a selective Rho-kinase inhibitor-
Uses vasodilator (cerebral), Ca antagonist A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced co ntraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho- associated Kinase (ROCK IC50= 10.7 uM). Fasudil is a protein kinase A inhibitor and may be used in medicinal combinations for hepatitis treatment.

Technology Process of Fasudil

There total 6 articles about Fasudil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%