(benzhydrylidene-amino)-(3-oxo-cyclohexyl)-acetic acid methyl ester

Base Information

• Chemical Name: (benzhydrylidene-amino)-(3-oxo-cyclohexyl)-acetic acid methyl ester
• CAS No.: 369598-87-8
• Molecular Formula: C₂₂H₂₃NO₃
• Molecular Weight: 349.43
• Mol file: 369598-87-8.mol

Synonyms:(benzhydrylidene-amino)-(3-oxo-cyclohexyl)-acetic acid methyl ester

Chemical Property of (benzhydrylidene-amino)-(3-oxo-cyclohexyl)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (benzhydrylidene-amino)-(3-oxo-cyclohexyl)-acetic acid methyl ester

There total 2 articles about (benzhydrylidene-amino)-(3-oxo-cyclohexyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

cyclohexenone (930-68-7) + methyl N-(diphenylmethylene)glycinate (81167-39-7) → (benzhydrylidene-amino)-(3-oxo-cyclohexyl)-acetic acid methyl ester (369598-87-8)

Guidance literature:

methyl N-(diphenylmethylene)glycinate; With copper(l) iodide; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.75h;

cyclohexenone; In tetrahydrofuran; at -78 - 20 ℃; for 18h;

DOI:10.1016/S0960-894X(01)00371-7

Reference yield:

Benzophenone imine (1013-88-3) → (benzhydrylidene-amino)-(3-oxo-cyclohexyl)-acetic acid methyl ester (369598-87-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 100 percent / CH₂Cl₂ / 4 h / 20 °C

2.1: LDA; CuI / tetrahydrofuran / 0.75 h / -78 °C

2.2: 85 percent / tetrahydrofuran / 18 h / -78 - 20 °C

With copper(l) iodide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(01)00371-7

Reference yield:

(benzhydrylidene-amino)-(3-oxo-cyclohexyl)-acetic acid methyl ester (369598-87-8) → amino-(3-oxo-cyclohexyl)-acetic acid methyl ester

Guidance literature:

With water; citric acid; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1016/S0960-894X(01)00371-7

upstream raw materials:

cyclohexenone

methyl N-(diphenylmethylene)glycinate

Benzophenone imine

Downstream raw materials:

Methyl N-{[4'-methoxy-(1,1'-biphenyl)-4-yl]-sulfonyl}-amino-(3-oxycyclohexan-1-yl)-acetate