methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate

Base Information

Chemical Name:methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate
CAS No.:1331942-96-1
Molecular Formula:C₁₇H₉F₄NO₈S
Molecular Weight:463.32
Hs Code.:

Synonyms:methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate

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Chemical Property of methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate

Chemical Property:

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Technology Process of methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate

There total 6 articles about methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 1331942-95-0
methyl 2-(4-fluorophenyl)-5-hydroxy-6-nitro-1-benzofuran-3-carboxylate

: 1331942-96-1
methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 0.833333h; Inert atmosphere;

Reference yield:

: 63131-29-3
methyl 4-fluorobenzoyl acetate

: 1331942-96-1
methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc(II) chloride / diethyl ether; methanol / 7.5 h / 75 - 115 °C / Inert atmosphere

2.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 60 °C / Inert atmosphere

3.1: nitric acid / chloroform / 1 h / -15 - 0 °C

4.1: boron trichloride / dichloromethane / 0.5 h / -15 °C / Inert atmosphere

4.2: Cooling with ice

5.1: dmap; triethylamine / dichloromethane / 0.83 h / 0 °C / Inert atmosphere

With dmap; nitric acid; boron trichloride; caesium carbonate; triethylamine; zinc(II) chloride; In 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; dichloromethane; chloroform;

Reference yield:

: 691856-96-9
methyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate

: 1331942-96-1
methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 20 h / 60 °C / Inert atmosphere

2.1: nitric acid / chloroform / 1 h / -15 - 0 °C

3.1: boron trichloride / dichloromethane / 0.5 h / -15 °C / Inert atmosphere

3.2: Cooling with ice

4.1: dmap; triethylamine / dichloromethane / 0.83 h / 0 °C / Inert atmosphere

With dmap; nitric acid; boron trichloride; caesium carbonate; triethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; chloroform;