6-amino-5,8-dimethyl-7-phenylisoquinoline

Base Information

• Chemical Name: 6-amino-5,8-dimethyl-7-phenylisoquinoline
• CAS No.: 123190-45-4
• Molecular Formula: C₁₇H₁₆N₂
• Molecular Weight: 248.327
• Mol file: 123190-45-4.mol

Synonyms:6-amino-5,8-dimethyl-7-phenylisoquinoline

Chemical Property of 6-amino-5,8-dimethyl-7-phenylisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-amino-5,8-dimethyl-7-phenylisoquinoline

There total 7 articles about 6-amino-5,8-dimethyl-7-phenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-amino-7-bromo-5,8-dimethylisoquinoline (123190-44-3) + phenylboronic acid (98-80-6) → 6-amino-5,8-dimethyl-7-phenylisoquinoline (123190-45-4)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In benzene; Heating;

DOI:10.1016/S0040-4039(00)95184-0

Reference yield:

2,5-Dimethylaniline (95-78-3) → 6-amino-5,8-dimethyl-7-phenylisoquinoline (123190-45-4)

Guidance literature:

Multi-step reaction with 12 steps

2: AlCl₃ / CS₂

3: AlCl₃, NaCl / 180 °C

4: aq. HCl / Heating

5: Br₂ / I₂ / CH₂Cl₂ / Ambient temperature

6: NEt₃ / tetrahydrofuran / Ambient temperature

7: NaBH₄ / methanol / 0 degC to room temp.

8: aq. H₂SO₄; tetrahydrofuran / Heating

9: NaOAc

11: aq. HCl / Heating

12: 99 percent / aq. 2M Na₂CO₃ / Pd(PPh₃)4 / benzene / Heating

With sodium tetrahydroborate; aluminium trichloride; bromine; sodium acetate; sodium carbonate; triethylamine; sodium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; In tetrahydrofuran; hydrogenchloride; methanol; carbon disulfide; dichloromethane; sulfuric acid; benzene;

DOI:10.1016/S0040-4039(00)95184-0

Reference yield:

5-acetamido-6-bromo-4,7-dimethylindan-1-one (123190-42-1) → 6-amino-5,8-dimethyl-7-phenylisoquinoline (123190-45-4)

Guidance literature:

Multi-step reaction with 6 steps

1: NaBH₄ / methanol / 0 degC to room temp.

2: aq. H₂SO₄; tetrahydrofuran / Heating

3: NaOAc

5: aq. HCl / Heating

6: 99 percent / aq. 2M Na₂CO₃ / Pd(PPh₃)4 / benzene / Heating

With sodium tetrahydroborate; sodium acetate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hydrogenchloride; methanol; sulfuric acid; benzene;

DOI:10.1016/S0040-4039(00)95184-0

upstream raw materials:

6-amino-7-bromo-5,8-dimethylisoquinoline

phenylboronic acid

2,5-Dimethylaniline

6-acetamido-5-bromo-4,7-dimethylindene

Downstream raw materials:

6-azido-5,8-dimethyl-7-phenylisoquinoline

ellipticine