Technology Process of 6-azido-5,8-dimethyl-7-phenylisoquinoline
There total 8 articles about 6-azido-5,8-dimethyl-7-phenylisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 13 steps
2: AlCl3 / CS2
3: AlCl3, NaCl / 180 °C
4: aq. HCl / Heating
5: Br2 / I2 / CH2Cl2 / Ambient temperature
6: NEt3 / tetrahydrofuran / Ambient temperature
7: NaBH4 / methanol / 0 degC to room temp.
8: aq. H2SO4; tetrahydrofuran / Heating
9: NaOAc
11: aq. HCl / Heating
12: 99 percent / aq. 2M Na2CO3 / Pd(PPh3)4 / benzene / Heating
13: 85 percent / 1) NaNO2, dil. HCl, 2) NaN3 / 1) 0 degC
With
hydrogenchloride; sodium tetrahydroborate; aluminium trichloride; sodium azide; bromine; sodium acetate; sodium carbonate; triethylamine; sodium chloride; sodium nitrite;
tetrakis(triphenylphosphine) palladium(0); iodine;
In
tetrahydrofuran; hydrogenchloride; methanol; carbon disulfide; dichloromethane; sulfuric acid; benzene;
DOI:10.1016/S0040-4039(00)95184-0
- Guidance literature:
-
Multi-step reaction with 7 steps
1: NaBH4 / methanol / 0 degC to room temp.
2: aq. H2SO4; tetrahydrofuran / Heating
3: NaOAc
5: aq. HCl / Heating
6: 99 percent / aq. 2M Na2CO3 / Pd(PPh3)4 / benzene / Heating
7: 85 percent / 1) NaNO2, dil. HCl, 2) NaN3 / 1) 0 degC
With
hydrogenchloride; sodium tetrahydroborate; sodium azide; sodium acetate; sodium carbonate; sodium nitrite;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; hydrogenchloride; methanol; sulfuric acid; benzene;
DOI:10.1016/S0040-4039(00)95184-0
