1-Methyl-3-(3-methyl-2,4,5-trimethoxyphenylmethyl)-5-thioxo-2-piperazinone

Base Information

• Chemical Name: 1-Methyl-3-(3-methyl-2,4,5-trimethoxyphenylmethyl)-5-thioxo-2-piperazinone
• CAS No.: 124867-33-0
• Molecular Formula: C₁₆H₂₂N₂O₄S
• Molecular Weight: 338.428
• Mol file: 124867-33-0.mol

Synonyms:1-Methyl-3-(3-methyl-2,4,5-trimethoxyphenylmethyl)-5-thioxo-2-piperazinone

Chemical Property of 1-Methyl-3-(3-methyl-2,4,5-trimethoxyphenylmethyl)-5-thioxo-2-piperazinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Methyl-3-(3-methyl-2,4,5-trimethoxyphenylmethyl)-5-thioxo-2-piperazinone

There total 1 articles about 1-Methyl-3-(3-methyl-2,4,5-trimethoxyphenylmethyl)-5-thioxo-2-piperazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.7%

1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione (120040-38-2) → 1-Methyl-3-(3-methyl-2,4,5-trimethoxyphenylmethyl)-5-thioxo-2-piperazinone (124867-33-0)

Guidance literature:

With Lawessons reagent; In 1,2-dimethoxyethane; for 12h; Ambient temperature;

DOI:10.1248/cpb.37.1493

Reference yield: 71.4%

triethyloxonium fluoroborate (368-39-8) + 1-Methyl-3-(3-methyl-2,4,5-trimethoxyphenylmethyl)-5-thioxo-2-piperazinone (124867-33-0) → 5-Ethylsulfanyl-1-methyl-3-(2,4,5-trimethoxy-3-methyl-benzyl)-3,6-dihydro-1H-pyrazin-2-one (124894-73-1)

Guidance literature:

In dichloromethane; for 1h; Ambient temperature;

DOI:10.1248/cpb.37.1493

Reference yield:

1-Methyl-3-(3-methyl-2,4,5-trimethoxyphenylmethyl)-5-thioxo-2-piperazinone (124867-33-0) → 1-Methyl-3-(3-methyl-2,4,5-trimethoxyphenylmethyl)-2-piperazinone (124867-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 71.4 percent / CH₂Cl₂ / 1 h / Ambient temperature

2: 59 percent / aluminium amalgam / tetrahydrofuran; H₂O / 4 h / 0 °C

With aluminium amalgam; In tetrahydrofuran; dichloromethane; water;

DOI:10.1248/cpb.37.1493

upstream raw materials:

1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

Downstream raw materials:

5-Ethylsulfanyl-1-methyl-3-(2,4,5-trimethoxy-3-methyl-benzyl)-3,6-dihydro-1H-pyrazin-2-one

1-Methyl-3-(3-methyl-2,4,5-trimethoxyphenylmethyl)-2-piperazinone

4-Ethoxymethyl-1-methyl-3-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazin-2-one