(3-Chloro-4-fluorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

Base Information

Chemical Name:(3-Chloro-4-fluorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol
CAS No.:1315380-40-5
Molecular Formula:C₁₇H₁₇ClFNO₃
Molecular Weight:337.778
Hs Code.:

Synonyms:(3-Chloro-4-fluorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

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Chemical Property of (3-Chloro-4-fluorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

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Technology Process of (3-Chloro-4-fluorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

There total 1 articles about (3-Chloro-4-fluorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 60811-21-4
1-bromo-3-chloro-4-fluorobenzene

: 6560-65-2
2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5-carboxaldehyde

: 1315380-40-5
(3-Chloro-4-fluorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

Guidance literature:: 1-bromo-3-chloro-4-fluorobenzene; With magnesium; In diethyl ether; for 2h; Inert atmosphere; Heating;

2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine-5-carboxaldehyde; In diethyl ether; at 20 ℃; Inert atmosphere;

With water; ammonium chloride; In diethyl ether; Inert atmosphere;

Reference yield:

: 1315380-40-5
(3-Chloro-4-fluorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

: 1315380-42-7
(3-Chloro-4-fluorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanone

Guidance literature:: With manganese(IV) oxide; In chloroform; for 2h; Reflux;

Reference yield:

: 1315380-40-5
(3-Chloro-4-fluorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol

: 1315380-44-9
(3-Chloro-4-fluorophenyl)(8-(hydroxymethyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: manganese(IV) oxide / chloroform / 2 h / Reflux

2: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.42 h

3: trifluoroacetic anhydride / dichloromethane / 14 h / Reflux

With manganese(IV) oxide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In dichloromethane; chloroform;