7-chloro-2-oxo-5-phenyl-3-propyl-2,3-dihydro-1H-1,4-benzodiazepin-4-ium-4-olate

Base Information

• Chemical Name: 7-chloro-2-oxo-5-phenyl-3-propyl-2,3-dihydro-1H-1,4-benzodiazepin-4-ium-4-olate
• CAS No.: 479676-59-0
• Molecular Formula: C₁₈H₁₇ClN₂O₂
• Molecular Weight: 328.798

Synonyms:7-chloro-2-oxo-5-phenyl-3-propyl-2,3-dihydro-1H-1,4-benzodiazepin-4-ium-4-olate

Chemical Property of 7-chloro-2-oxo-5-phenyl-3-propyl-2,3-dihydro-1H-1,4-benzodiazepin-4-ium-4-olate

Chemical Property:

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Technology Process of 7-chloro-2-oxo-5-phenyl-3-propyl-2,3-dihydro-1H-1,4-benzodiazepin-4-ium-4-olate

There total 3 articles about 7-chloro-2-oxo-5-phenyl-3-propyl-2,3-dihydro-1H-1,4-benzodiazepin-4-ium-4-olate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-bromo-N-{4-chloro-2-[(hydroxyimino)(phenyl)methyl]phenyl}pentanamide → 7-chloro-2-oxo-5-phenyl-3-propyl-2,3-dihydro-1H-1,4-benzodiazepin-4-ium-4-olate (479676-59-0)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 40 ℃; for 3.5h;

DOI:10.1211/0022357021779005

Reference yield:

2-bromopentanoyl chloride (42768-45-6) → 7-chloro-2-oxo-5-phenyl-3-propyl-2,3-dihydro-1H-1,4-benzodiazepin-4-ium-4-olate (479676-59-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / 1,2-dichloro-ethane / 3.5 h / Heating

2: 60 percent / NaOH / ethanol; H₂O / 3.5 h / 40 °C

With sodium hydroxide; In ethanol; water; 1,2-dichloro-ethane;

DOI:10.1211/0022357021779005

Reference yield:

(2-amino-5-chlorophenyl)(phenyl)methanone oxime (15185-66-7) → 7-chloro-2-oxo-5-phenyl-3-propyl-2,3-dihydro-1H-1,4-benzodiazepin-4-ium-4-olate (479676-59-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / 1,2-dichloro-ethane / 3.5 h / Heating

2: 60 percent / NaOH / ethanol; H₂O / 3.5 h / 40 °C

With sodium hydroxide; In ethanol; water; 1,2-dichloro-ethane;

DOI:10.1211/0022357021779005

upstream raw materials:

2-bromopentanoyl chloride

(2-amino-5-chlorophenyl)(phenyl)methanone oxime

Downstream raw materials:

7-chloro-5-phenyl-3-propyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

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