2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine

Base Information

Chemical Name:2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine
CAS No.:121649-01-2
Molecular Formula:C₁₃H₂₀FNO₂
Molecular Weight:241.306
Hs Code.:
UNII:72UT55MXE3
ChEMBL ID:CHEMBL123685
DSSTox Substance ID:DTXSID00557322
Wikidata:Q4596787
Wikipedia:2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine

Synonyms:Doef;2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine;72UT55MXE3;UNII-72UT55MXE3;121649-01-2;4-(2-Fluoroethyl)-2,5-dimethoxy-alpha-methylbenzeneethanamine;Benzeneethanamine, 4-(2-fluoroethyl)-2,5-dimethoxy-alpha-methyl-, (+/-)-;CHEMBL123685;SCHEMBL5305075;DTXSID00557322;Q4596787;1-[4-(2-Fluoroethyl)-2,5-dimethoxyphenyl]-2-propanamine;4-(2-FLUOROETHYL)-2,5-DIMETHOXY-.ALPHA.-METHYLBENZENEETHANAMINE;BENZENEETHANAMINE, 4-(2-FLUOROETHYL)-2,5-DIMETHOXY-.ALPHA.-METHYL-, (+/-)-

Suppliers and Price of 2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of 2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine

Chemical Property:

Boiling Point:338.6±42.0 °C(Predicted)
Density:1.053±0.06 g/cm3(Predicted)
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:241.14780704
Heavy Atom Count:17
Complexity:216

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC1=C(C=C(C(=C1)OC)CCF)OC)N

Technology Process of 2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine

There total 12 articles about 2,5-Dimethoxy-4-(2-fluoroethyl)amphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 121649-07-8
(+/-)-1-<2,5-Dimethoxy-4-(2-fluoroethyl)phenyl>-2-trifluoroacetamidopropane

: 121649-01-2
4-(2-Fluoroethyl)-2,5-dimethoxyamphetamine

Guidance literature:: With potassium hydroxide; In water; isopropyl alcohol; at 45 ℃; for 0.5h;
DOI:10.1016/S0040-4039(00)82391-6

Reference yield:

: 7417-19-8
2-(2,5-dimethoxyphenyl)ethanol

: 121649-01-2
4-(2-Fluoroethyl)-2,5-dimethoxyamphetamine

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) sodium hydride / 1.) THF, reflux, 16 h, 2.) THF, 0 deg C, 15 min, 20 deg C, 10 h

2: 24 percent / POCl₃ / 0.17 h / 100 °C

3: 70 percent / NH₄OAc / 2 h / 100 °C

4: 95 percent / aluminium hydride, 100percent H₂SO₄ / tetrahydrofuran / 0 deg C, 20 deg C 1 h followed 30 min reflux

5: 57 percent / TMSCl, Et₃N, TMSI / CH₂Cl₂; CHCl₃

6: 89 percent / Et₃N / diethyl ether / 1 h / 0 - 35 °C

7: 96 percent / pyridine / 12 h / 0 °C

8: 55 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Heating

9: 86 percent / KOH / H₂O; propan-2-ol / 0.5 h / 45 °C

With pyridine; aluminium hydride; potassium hydroxide; chloro-trimethyl-silane; trimethylsilyl iodide; sulfuric acid; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; trichlorophosphate; ammonium acetate; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; water; isopropyl alcohol;
DOI:10.1016/S0040-4039(00)82391-6

Reference yield:

: 16162-59-7
1,4-dimethoxy-2-(2-methoxyethyl)benzene

: 121649-01-2
4-(2-Fluoroethyl)-2,5-dimethoxyamphetamine

Guidance literature:: Multi-step reaction with 8 steps

1: 24 percent / POCl₃ / 0.17 h / 100 °C

2: 70 percent / NH₄OAc / 2 h / 100 °C

3: 95 percent / aluminium hydride, 100percent H₂SO₄ / tetrahydrofuran / 0 deg C, 20 deg C 1 h followed 30 min reflux

4: 57 percent / TMSCl, Et₃N, TMSI / CH₂Cl₂; CHCl₃

5: 89 percent / Et₃N / diethyl ether / 1 h / 0 - 35 °C

6: 96 percent / pyridine / 12 h / 0 °C

7: 55 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Heating

8: 86 percent / KOH / H₂O; propan-2-ol / 0.5 h / 45 °C

With pyridine; aluminium hydride; potassium hydroxide; chloro-trimethyl-silane; trimethylsilyl iodide; sulfuric acid; tetrabutyl ammonium fluoride; triethylamine; trichlorophosphate; ammonium acetate; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; water; isopropyl alcohol;
DOI:10.1016/S0040-4039(00)82391-6