Phosphoric acid dibenzyl ester 3-[(S)-4-(2,5-difluoro-phenyl)-1-((S)-2-hydroxy-3,3-dimethyl-butyryl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

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Chemical Name:Phosphoric acid dibenzyl ester 3-[(S)-4-(2,5-difluoro-phenyl)-1-((S)-2-hydroxy-3,3-dimethyl-butyryl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester
CAS No.:884651-24-5
Molecular Formula:C₃₆H₃₆F₂NO₆P
Molecular Weight:647.656
Hs Code.:

Synonyms:Phosphoric acid dibenzyl ester 3-[(S)-4-(2,5-difluoro-phenyl)-1-((S)-2-hydroxy-3,3-dimethyl-butyryl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

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Chemical Property of Phosphoric acid dibenzyl ester 3-[(S)-4-(2,5-difluoro-phenyl)-1-((S)-2-hydroxy-3,3-dimethyl-butyryl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

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Technology Process of Phosphoric acid dibenzyl ester 3-[(S)-4-(2,5-difluoro-phenyl)-1-((S)-2-hydroxy-3,3-dimethyl-butyryl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

There total 7 articles about Phosphoric acid dibenzyl ester 3-[(S)-4-(2,5-difluoro-phenyl)-1-((S)-2-hydroxy-3,3-dimethyl-butyryl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 639074-95-6
3-{(2S)-4-(2,5-difluorophenyl)-1-[(2S)-2-hydroxy-3,3-dimethylbutanoyl]-2,5-dihydro-1H-pyrrol-2-yl}phenol

: 17176-77-1
Dibenzyl phosphite

: 884651-24-5
Phosphoric acid dibenzyl ester 3-[(S)-4-(2,5-difluoro-phenyl)-1-((S)-2-hydroxy-3,3-dimethyl-butyryl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

Guidance literature:: With tetrachloromethane; dmap; N,N-diethyl-N-isopropylamine; In acetonitrile; at 0 - 25 ℃;
DOI:10.1016/j.bmcl.2005.12.094

Reference yield:

: 635724-41-3
tert-butyl 3-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

: 884651-24-5
Phosphoric acid dibenzyl ester 3-[(S)-4-(2,5-difluoro-phenyl)-1-((S)-2-hydroxy-3,3-dimethyl-butyryl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Pd(OAc)2; Ph₃As / 0.5 h / 150 °C / microwave irradiation

2: 95 percent / TFA / CH₂Cl₂

3: PyBOP; Et₃N / dimethylformamide

4: 90 percent / K₂CO₃ / dimethylformamide

5: 84 percent / i-PrNEt₂; DMAP; CCl₄ / acetonitrile / 0 - 25 °C

With tetrachloromethane; dmap; palladium diacetate; N,N-diethyl-N-isopropylamine; triphenyl-arsane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: Heck coupling;
DOI:10.1016/j.bmcl.2005.12.094

Reference yield:

: 884651-22-3
2-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2,5-difluoro-phenyl)-2,5-dihydro-1H-pyrrole

: 884651-24-5
Phosphoric acid dibenzyl ester 3-[(S)-4-(2,5-difluoro-phenyl)-1-((S)-2-hydroxy-3,3-dimethyl-butyryl)-2,5-dihydro-1H-pyrrol-2-yl]-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: PyBOP; Et₃N / dimethylformamide

2: 90 percent / K₂CO₃ / dimethylformamide

3: 84 percent / i-PrNEt₂; DMAP; CCl₄ / acetonitrile / 0 - 25 °C

With tetrachloromethane; dmap; N,N-diethyl-N-isopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.12.094