N-{4-[1-(piperidine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

Base Information

Chemical Name:N-{4-[1-(piperidine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine
CAS No.:1204329-53-2
Molecular Formula:C₂₀H₂₆F₃N₅O₂
Molecular Weight:425.454
Hs Code.:

Synonyms:N-{4-[1-(piperidine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

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Chemical Property of N-{4-[1-(piperidine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

Chemical Property:

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Technology Process of N-{4-[1-(piperidine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

There total 13 articles about N-{4-[1-(piperidine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₄₂F₃N₅O₆

: 1204329-53-2
N-{4-[1-(piperidine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 107317-58-8
4-bromo-3-trifluoromethylbenzoic acid methyl ester

: 1204329-53-2
N-{4-[1-(piperidine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 140 °C / Sealed tube

2.1: hydrogen; acetic acid / platinum(IV) oxide / 60 h / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; water / 3 h / 50 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5.1: water; potassium carbonate / methanol / 16 h / 20 °C

6.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.5 h

6.2: 2 h

7.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 16 h / Inert atmosphere

8.1: HATU / N,N-dimethyl acetamide / 0.25 h / 20 °C

8.2: 16 h / 20 °C

9.1: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogenchloride; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium hydroxide, 20 wt% on carbon; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; 1.1: Suzuki Coupling;

Reference yield:

: 161622-14-6
4-bromo-3-(trifluoromethyl)benzoic acid

: 1204329-53-2
N-{4-[1-(piperidine-3-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-guanidine

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid / 80 °C / Sealed tube

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 140 °C / Sealed tube

3.1: hydrogen; acetic acid / platinum(IV) oxide / 60 h / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; water / 3 h / 50 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

6.1: water; potassium carbonate / methanol / 16 h / 20 °C

7.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.5 h

7.2: 2 h

8.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 16 h / Inert atmosphere

9.1: HATU / N,N-dimethyl acetamide / 0.25 h / 20 °C

9.2: 16 h / 20 °C

10.1: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogenchloride; sulfuric acid; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium hydroxide, 20 wt% on carbon; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; 2.1: Suzuki Coupling;