(R)-methyl 6-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-6-oxohexanoate

Base Information

Chemical Name:(R)-methyl 6-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-6-oxohexanoate
CAS No.:1415336-39-8
Molecular Formula:C₃₂H₃₄N₂O₇
Molecular Weight:558.631
Hs Code.:

Synonyms:(R)-methyl 6-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-6-oxohexanoate

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Chemical Property of (R)-methyl 6-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-6-oxohexanoate

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Technology Process of (R)-methyl 6-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-6-oxohexanoate

There total 5 articles about (R)-methyl 6-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-6-oxohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1415336-38-7
methyl 6-(2-amino-4-methoxyphenyl)-6-oxohexanoate

: 144073-15-4
(9H-fluoren-9-yl)methyl (R)-(1-chloro-1-oxopropan-2-yl)carbamate

: 1415336-39-8
(R)-methyl 6-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-6-oxohexanoate

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ol303149k

Reference yield:

: 1415336-37-6
methyl 6-(2-acetamido-4-methoxyphenyl)-6-oxohexanoate

: 1415336-39-8
(R)-methyl 6-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-6-oxohexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol; water / 4 h / Reflux; Inert atmosphere

2: thionyl chloride / methanol / 16 h / 0 - 20 °C / Inert atmosphere

3: sodium hydrogencarbonate / water; dichloromethane / 6 h / 20 °C / Inert atmosphere

With hydrogenchloride; thionyl chloride; sodium hydrogencarbonate; In methanol; dichloromethane; water;
DOI:10.1021/ol303149k

Reference yield:

: 6654-36-0
methyl 6-oxohexanoate

: 1415336-39-8
(R)-methyl 6-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-6-oxohexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium(II) trifluoroacetate / toluene / Inert atmosphere; Sealed tube

1.2: 24 h / 90 °C / Inert atmosphere

2.1: hydrogenchloride / methanol; water / 4 h / Reflux; Inert atmosphere

3.1: thionyl chloride / methanol / 16 h / 0 - 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / water; dichloromethane / 6 h / 20 °C / Inert atmosphere

With hydrogenchloride; thionyl chloride; palladium(II) trifluoroacetate; sodium hydrogencarbonate; In methanol; dichloromethane; water; toluene;
DOI:10.1021/ol303149k