4-((benzyl(3-(pyrimidin-2-ylamino)propyl)amino)methyl)-N'-phenylbenzohydrazide

Base Information

Chemical Name:4-((benzyl(3-(pyrimidin-2-ylamino)propyl)amino)methyl)-N'-phenylbenzohydrazide
CAS No.:1059145-23-1
Molecular Formula:C₂₈H₃₀N₆O
Molecular Weight:466.586
Hs Code.:

Synonyms:4-((benzyl(3-(pyrimidin-2-ylamino)propyl)amino)methyl)-N'-phenylbenzohydrazide

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Chemical Property of 4-((benzyl(3-(pyrimidin-2-ylamino)propyl)amino)methyl)-N'-phenylbenzohydrazide

Chemical Property:

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Technology Process of 4-((benzyl(3-(pyrimidin-2-ylamino)propyl)amino)methyl)-N'-phenylbenzohydrazide

There total 9 articles about 4-((benzyl(3-(pyrimidin-2-ylamino)propyl)amino)methyl)-N'-phenylbenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1722-12-9,1195939-87-7
2-chloropyrimidine

: 1059145-20-8
4-(((3-aminopropyl)(benzyl)amino)methyl)-N'-phenylbenzohydrazide

: 1059145-23-1
4-((benzyl(3-(pyrimidin-2-ylamino)propyl)amino)methyl)-N'-phenylbenzohydrazide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 90 ℃; for 24h;

Reference yield:

: 100-46-9
benzylamine

: 1059145-23-1
4-((benzyl(3-(pyrimidin-2-ylamino)propyl)amino)methyl)-N'-phenylbenzohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / methanol; 1,2-dichloro-ethane / 0.25 h / 20 °C

1.2: 16 h / 60 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 17 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; sodium iodide / acetonitrile / 48 h / Heating / reflux

4.1: hydrazine / methanol / 18 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 90 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide; hydrazine; acetic acid; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 619-66-9
4-Carboxybenzaldehyde

: 1059145-23-1
4-((benzyl(3-(pyrimidin-2-ylamino)propyl)amino)methyl)-N'-phenylbenzohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / methanol; 1,2-dichloro-ethane / 0.25 h / 20 °C

1.2: 16 h / 60 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 17 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; sodium iodide / acetonitrile / 48 h / Heating / reflux

4.1: hydrazine / methanol / 18 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 90 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide; hydrazine; acetic acid; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;