2-propanyl 4-[(3S,5aR,6R,7R,8aS)-6-[(1E)-4-phenoxy-1-buten-1-yl]-7-(tetrahydro-2H-pyran-2-yloxy)octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoate

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Chemical Name:2-propanyl 4-[(3S,5aR,6R,7R,8aS)-6-[(1E)-4-phenoxy-1-buten-1-yl]-7-(tetrahydro-2H-pyran-2-yloxy)octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoate
CAS No.:1262875-19-3
Molecular Formula:C₃₁H₄₆O₆
Molecular Weight:514.703
Hs Code.:

Synonyms:2-propanyl 4-[(3S,5aR,6R,7R,8aS)-6-[(1E)-4-phenoxy-1-buten-1-yl]-7-(tetrahydro-2H-pyran-2-yloxy)octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoate

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Chemical Property of 2-propanyl 4-[(3S,5aR,6R,7R,8aS)-6-[(1E)-4-phenoxy-1-buten-1-yl]-7-(tetrahydro-2H-pyran-2-yloxy)octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoate

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Technology Process of 2-propanyl 4-[(3S,5aR,6R,7R,8aS)-6-[(1E)-4-phenoxy-1-buten-1-yl]-7-(tetrahydro-2H-pyran-2-yloxy)octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoate

There total 20 articles about 2-propanyl 4-[(3S,5aR,6R,7R,8aS)-6-[(1E)-4-phenoxy-1-buten-1-yl]-7-(tetrahydro-2H-pyran-2-yloxy)octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262875-18-2
5-[(3-phenoxypropyl)sulfonyl]-1-phenyl-1H-tetrazole

: 1262872-79-6
2-propanyl 4-[(3S,5aR,6R,7R,8aS)-6-formyl-7-(tetrahydro-2H-pyran-2-yloxy)octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoate

: 1262875-19-3
2-propanyl 4-[(3S,5aR,6R,7R,8aS)-6-[(1E)-4-phenoxy-1-buten-1-yl]-7-(tetrahydro-2H-pyran-2-yloxy)octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoate

Guidance literature:: 5-[(3-phenoxypropyl)sulfonyl]-1-phenyl-1H-tetrazole; With potassium hexamethylsilazane; In 1,2-dimethoxyethane; toluene; at -78 ℃; for 0.333333h; Inert atmosphere;

2-propanyl 4-[(3S,5aR,6R,7R,8aS)-6-formyl-7-(tetrahydro-2H-pyran-2-yloxy)octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoate; In 1,2-dimethoxyethane; at -78 ℃; for 0.166667h;

Reference yield:

: 65025-95-8
(3aR,4S,5R,6aS)-4-({[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one

: 1262875-19-3
2-propanyl 4-[(3S,5aR,6R,7R,8aS)-6-[(1E)-4-phenoxy-1-buten-1-yl]-7-(tetrahydro-2H-pyran-2-yloxy)octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoate

Guidance literature:: Multi-step reaction with 13 steps

1.1: diisobutylaluminium hydride / toluene / 1.5 h / -70 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Cooling with ice

2.2: 3.5 h / -70 - 20 °C

3.1: sodium hydride / mineral oil / 0.08 h / 5 °C / Inert atmosphere

3.2: 2.83 h / 20 °C

4.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene; tetrahydrofuran / 2 h / 20 - 80 °C / Inert atmosphere

5.1: bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum / toluene / 18 h / 85 °C / Inert atmosphere

6.1: sodium hydroxide; water / ethanol / 2 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

8.1: hydrogen / (η4-1,5-cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate / dichloromethane / 3.83 h / 20 °C / Inert atmosphere

9.1: dimethylaluminum chloride / dichloromethane; hexane / 3.67 h / -20 °C / Inert atmosphere

10.1: toluene-4-sulfonic acid / toluene / 1 h / 20 °C / Inert atmosphere

11.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2.83 h / 45 °C / Inert atmosphere

12.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / ethyl acetate; dimethyl sulfoxide / 0.67 h / 0 °C / Inert atmosphere

13.1: potassium hexamethylsilazane / toluene; 1,2-dimethoxyethane / 0.33 h / -78 °C / Inert atmosphere

13.2: 0.17 h / -78 °C

With tetrabutyl ammonium fluoride; water; hydrogen; dimethylaluminum chloride; sulfur trioxide pyridine complex; potassium hexamethylsilazane; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum; bis(tri-t-butylphosphine)palladium⁽⁰⁾; (η4-1,5-cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 92134-19-5
(1S,2R,3S,4R)-2-allyl-3-({[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)-4-(tetrahydro-2H-pyran-2-yloxy)cyclopentanol

: 1262875-19-3
2-propanyl 4-[(3S,5aR,6R,7R,8aS)-6-[(1E)-4-phenoxy-1-buten-1-yl]-7-(tetrahydro-2H-pyran-2-yloxy)octahydro-2H-cyclopenta[b]oxepin-3-yl]butanoate

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium hydride / mineral oil / 0.08 h / 5 °C / Inert atmosphere

1.2: 2.83 h / 20 °C

2.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene; tetrahydrofuran / 2 h / 20 - 80 °C / Inert atmosphere

3.1: bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum / toluene / 18 h / 85 °C / Inert atmosphere

4.1: sodium hydroxide; water / ethanol / 2 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

6.1: hydrogen / (η4-1,5-cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate / dichloromethane / 3.83 h / 20 °C / Inert atmosphere

7.1: dimethylaluminum chloride / dichloromethane; hexane / 3.67 h / -20 °C / Inert atmosphere

8.1: toluene-4-sulfonic acid / toluene / 1 h / 20 °C / Inert atmosphere

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2.83 h / 45 °C / Inert atmosphere

10.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / ethyl acetate; dimethyl sulfoxide / 0.67 h / 0 °C / Inert atmosphere

11.1: potassium hexamethylsilazane / toluene; 1,2-dimethoxyethane / 0.33 h / -78 °C / Inert atmosphere

11.2: 0.17 h / -78 °C

With tetrabutyl ammonium fluoride; water; hydrogen; dimethylaluminum chloride; sulfur trioxide pyridine complex; potassium hexamethylsilazane; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; bis[1,1-di(trifluoromethyl)ethoxy][(2,6-diisopropylphenyl)imino](2-methyl-2-phenylpropylidene)molybdenum; bis(tri-t-butylphosphine)palladium⁽⁰⁾; (η4-1,5-cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;