2-(1-methyl-1-methoxycarbonylethyl)-6-bromo-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

Base Information

Chemical Name:2-(1-methyl-1-methoxycarbonylethyl)-6-bromo-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one
CAS No.:335278-76-7
Molecular Formula:C₁₉H₁₉BrFN₃O₃
Molecular Weight:436.281
Hs Code.:

Synonyms:2-(1-methyl-1-methoxycarbonylethyl)-6-bromo-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

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Chemical Property of 2-(1-methyl-1-methoxycarbonylethyl)-6-bromo-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

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Technology Process of 2-(1-methyl-1-methoxycarbonylethyl)-6-bromo-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

There total 3 articles about 2-(1-methyl-1-methoxycarbonylethyl)-6-bromo-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 446-48-0
o-fluorobenzyl bromide

: 335278-75-6
2-(1-methyl-1-methoxycarbonylethyl)-6-bromo-7-methylimidazolo[1,2-a]pyrimid-5-one

: 335278-76-7
2-(1-methyl-1-methoxycarbonylethyl)-6-bromo-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1021/jm0205402

Reference yield:

: 38923-57-8
methyl 2,2-dimethyl-3-oxobutanoate

: 335278-76-7
2-(1-methyl-1-methoxycarbonylethyl)-6-bromo-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: Br₂; AlCl₃ / diethyl ether / 0 - 20 °C

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 76 percent / dimethylformamide / 20 °C

3.1: 58 percent / TBAF / 1,2-dichloro-ethane; tetrahydrofuran

With aluminium trichloride; tetrabutyl ammonium fluoride; bromine; sodium hydride; In tetrahydrofuran; diethyl ether; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205402

Reference yield:

: 84691-57-6
4-bromo-2,2-dimethyl acetoacetic acid methyl ester

: 335278-76-7
2-(1-methyl-1-methoxycarbonylethyl)-6-bromo-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 76 percent / dimethylformamide / 20 °C

2.1: 58 percent / TBAF / 1,2-dichloro-ethane; tetrahydrofuran

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205402