(Z)-methyl 2-isocyano-3-(4-methoxyphenyl)-3-phenylacrylate

Base Information

• Chemical Name: (Z)-methyl 2-isocyano-3-(4-methoxyphenyl)-3-phenylacrylate
• CAS No.: 1610565-02-0
• Molecular Formula: C₁₈H₁₅NO₃
• Molecular Weight: 293.322
• Mol file: 1610565-02-0.mol

Synonyms:(Z)-methyl 2-isocyano-3-(4-methoxyphenyl)-3-phenylacrylate

Chemical Property of (Z)-methyl 2-isocyano-3-(4-methoxyphenyl)-3-phenylacrylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (Z)-methyl 2-isocyano-3-(4-methoxyphenyl)-3-phenylacrylate

There total 2 articles about (Z)-methyl 2-isocyano-3-(4-methoxyphenyl)-3-phenylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H17NO4 (1610565-69-9) → (E)-methyl 2-isocyano-3-(4-methoxyphenyl)-3-phenylacrylate + (Z)-methyl 2-isocyano-3-(4-methoxyphenyl)-3-phenylacrylate (1610565-02-0)

Guidance literature:

With triethylamine; trichlorophosphate; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c4cc01122h

Reference yield:

4-Methoxybenzophenone (611-94-9) → (Z)-methyl 2-isocyano-3-(4-methoxyphenyl)-3-phenylacrylate (1610565-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / mineral oil; tetrahydrofuran / 2 h / 20 °C

2: triethylamine; trichlorophosphate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

With sodium hydride; triethylamine; trichlorophosphate; In tetrahydrofuran; mineral oil;

DOI:10.1039/c4cc01122h

Reference yield: 79.0%

diphenyliodonium tetrafluoroborate + (Z)-methyl 2-isocyano-3-(4-methoxyphenyl)-3-phenylacrylate (1610565-02-0) → methyl 7-methoxy-1,4-diphenylisoquinoline-3-carboxylate (1610565-23-5)

Guidance literature:

With tris[2-phenylpyridinato-C²,N]iridium(III); sodium carbonate; In methanol; at 26 ℃; for 24h; Inert atmosphere; Irradiation;

DOI:10.1039/c4cc01122h

upstream raw materials:

C₁₈H₁₇NO₄

4-Methoxybenzophenone

Downstream raw materials:

methyl 7-methoxy-1,4-diphenylisoquinoline-3-carboxylate