4-Methoxybenzophenone

Base Information

• Chemical Name: 4-Methoxybenzophenone
• CAS No.: 611-94-9
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• Hs Code.: 29145000
• European Community (EC) Number: 210-285-5
• NSC Number: 2194
• UNII: I4XJ07373M
• DSSTox Substance ID: DTXSID00209995
• Nikkaji Number: J96.106J
• Wikidata: Q27280450
• ChEMBL ID: CHEMBL198085
• Mol file: 611-94-9.mol

Synonyms:4-methoxybenzophenone

Chemical Property of 4-Methoxybenzophenone

Chemical Property:

• Appearance/Colour: White to yellow-orange crystalline solid
• Vapor Pressure: 3.22E-05mmHg at 25°C
• Melting Point: 60-63 °C(lit.)
• Refractive Index: 1.568
• Boiling Point: 355 °C at 760 mmHg
• Flash Point: 155.7 °C
• PSA: 26.30000
• Density: 1.108 g/cm³
• LogP: 2.92620
• Storage Temp.: Store below +30°C.
• Solubility.: almost transparency in Methanol
• Water Solubility.: Insoluble in water.
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 212.083729621
• Heavy Atom Count: 16
• Complexity: 223

Purity/Quality:

99% ^*data from raw suppliers

4-Methoxybenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2=CC=CC=C2
• Uses: 4-Methoxybenzophenone and its analogues showed diverse plant growth-regulating actions such as inhibition of shoot and root growth, induction of chlorosis, and a disturbance in phototropism or geotrop ism. 4-Methoxybenzophenone is also used as a photopolymerization catalyst. 4-Methoxybenzophenone and its analogues showed diverse plant growth-regulating actions such as inhibition of shoot and root growth, induction of chlorosis, and a disturbance in phototropism or geotropism. It is also used as a photo polymerization catalyst.

Technology Process of 4-Methoxybenzophenone

There total 538 articles about 4-Methoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4-methoxyphenyl)(phenyl)methanone oxime (24316-60-7) → 4-Methoxybenzophenone (611-94-9)

Guidance literature:

With tert.-butylhydroperoxide; In tetrachloromethane; for 4h; Heating;

DOI:10.1016/S0040-4039(96)02384-2

Reference yield: 100.0%

1-(4-methoxyphenyl)-1-phenylmethanol (720-44-5) → 4-Methoxybenzophenone (611-94-9)

Guidance literature:

With oxygen; sodium acetate; (neocuproine)Pd(OAc)2; In water; dimethyl sulfoxide; at 80 ℃; for 4h; under 22502.3 Torr;

DOI:10.1002/adsc.200303134

Reference yield: 99.0%

(phenyl)(p-methoxyphenyl)methanol acetate (38513-66-5) → 4-Methoxybenzophenone (611-94-9)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In water; chlorobenzene; at 130 ℃; for 1h; Temperature;

upstream raw materials:

1-(4-methoxyphenyl)-1-phenylmethanol

2-(4-methoxy-phenyl)-2-phenylacetaldehyde

chromium(lll) acetate

p-benzylanizole

Downstream raw materials:

[2]quinolyl-(4-methoxy-phenyl)-phenyl-methanol

1-(4-methoxyphenyl)-1-phenylethene

4-hydroxy-4-(4-methoxy-phenyl)-4-phenyl-but-2-ynoic acid amide

4,4'-dimethoxytrityl alcohol

Refernces

• 1、 Hardacre, Christopher,Nancarrow, Paul,Rooney, David W.,Thompson, Julian M.. "Friedel-crafts benzoylation of anisole in ionic liquids: Catalysis, separation, and recycle studies". . p. 1156 - 1163. Retrieved 2008.
• 2、 Yadav,Asthana,Kamble. "Cesium-substituted dodecatungstophosphoric acid on K-10 clay for benzoylation of anisole with benzoyl chloride". . p. 88 - 99. Retrieved 2003.
• 3、 Hardacre, Christopher,Katdare, Suhas P.,Milroy, David,Nancarrow, Paul,Rooney, David W.,Thompson, Jillian M.. "A catalytic and mechanistic study of the Friedel-Crafts benzoylation of anisole using zeolites in ionic liquids". . p. 44 - 52. Retrieved 2004.
• 4、 Aghajani, Zahra,Najafi, Gholam Reza,Sabaghi, Maryam. "Fabrication of a new heterogeneous tungstate-based on the amino-functionalized metal-organic framework as an efficient catalyst towards sonochemical oxidation of alcohols under green condition". . . Retrieved 2020.
• 5、 ?těpni?ka, Petr,Císa?ová, Ivana,Horky, Filip. "Synthesis, coordination and catalytic use of phosphinoferrocene ligands bearing 6-phospha-2,4,6-trioxaadamantane P-donor moieties". . . Retrieved 2021/11/11.
• 6、 Braje, Wilfried,Geneste, Hervé,Rodrigo, Eduardo,Walter, Magnus W.,Wiechert, Rainer. "One-step hydroxylation of aryl and heteroaryl fluorides using mechanochemistry". supporting information. p. 1469 - 1473. Retrieved 2022/03/07.